Sequence and organization of the human mitochondrial genome

S. Anderson, A. T. Bankier, B. G. Barrell, M. H.L. De Bruijn, A. R. Coulson, J. Drouin, I. C. Eperon, D. P. Nierlich, B. A. Roe, F. Sanger, P. H. Schreier, A. J.H. Smith, R. Staden, I. G. Young

Research output: Contribution to journalArticle

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Abstract

The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.

Original languageEnglish (US)
Pages (from-to)457-465
Number of pages9
JournalNature
Volume290
Issue number5806
DOIs
StatePublished - Dec 1 1981

All Science Journal Classification (ASJC) codes

  • General

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    Anderson, S., Bankier, A. T., Barrell, B. G., De Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., Schreier, P. H., Smith, A. J. H., Staden, R., & Young, I. G. (1981). Sequence and organization of the human mitochondrial genome. Nature, 290(5806), 457-465. https://doi.org/10.1038/290457a0