Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines

Naisheng Bai; Ching Shu Lai; Kan He; Zhu Zhou; Li Zhang; Zheng Quan; Nanqun Zhu; Qun Yi Zheng; Min Hsiung Pan; Chi Tang Ho

doi:10.1021/np050437q

Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines

Naisheng Bai, Ching Shu Lai, Kan He, Zhu Zhou, Li Zhang, Zheng Quan, Nanqun Zhu, Qun Yi Zheng, Min Hsiung Pan, Chi Tang Ho

School of Environmental and Biological Sciences, Food Science

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field ID and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS cancer cells. Compounds 3 and 4, two α-methylene γ-lactone-bearing sesquiterpenes, were modestly active in these assays.

Original language	American English
Pages (from-to)	531-535
Number of pages	5
Journal	Journal of Natural Products
Volume	69
Issue number	4
DOIs	https://doi.org/10.1021/np050437q
State	Published - Apr 2006

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines",

abstract = "Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field ID and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS cancer cells. Compounds 3 and 4, two α-methylene γ-lactone-bearing sesquiterpenes, were modestly active in these assays.",

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AU - Bai, Naisheng

AU - Lai, Ching Shu

AU - He, Kan

AU - Zhou, Zhu

AU - Zhang, Li

AU - Quan, Zheng

AU - Zhu, Nanqun

AU - Zheng, Qun Yi

AU - Pan, Min Hsiung

AU - Ho, Chi Tang

PY - 2006/4

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Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines

Abstract

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