Short- and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein

Paromita Banerjee, Brian P. Schoenfeld, Aaron J. Bell, Catherine H. Choi, Michael P. Bradley, Paul Hinchey, Maria Kollaros, Jae H. Park, Sean McBride, Thomas C. Dockendorff

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The diversity of protein isoforms arising from alternative splicing is thought to modulate fine-tuning of synaptic plasticity. Fragile X mental retardation protein (FMRP), a neuronal RNA binding protein, exists in isoforms as a result of alternative splicing, but the contribution of these isoforms to neural plasticity are not well understood. We show that two isoforms of Drosophila melanogaster FMRP (dFMR1) have differential roles in mediating neural development and behavior functions conferred by the dfmr1 gene. These isoforms differ in the presence of a protein interaction module that is related to prion domains and is functionally conserved between FMRPs. Expression of both isoforms is necessary for optimal performance in tests of short-and long-term memory of courtship training. The presence or absence of the protein interaction domain may govern the types of ribonucleoprotein (RNP) complexes dFMR1 assembles into, with different RNPs regulating gene expression in a manner necessary for establishing distinct phases of memory formation.

Original languageEnglish (US)
Pages (from-to)6782-6792
Number of pages11
JournalJournal of Neuroscience
Volume30
Issue number19
DOIs
StatePublished - May 12 2010

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Fragile X Mental Retardation Protein
Long-Term Memory
Protein Isoforms
Neuronal Plasticity
Alternative Splicing
Protein Interaction Domains and Motifs
Courtship
Ribonucleoproteins
RNA-Binding Proteins
Prions
Drosophila melanogaster
Short-Term Memory
Learning
Gene Expression

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Banerjee, P., Schoenfeld, B. P., Bell, A. J., Choi, C. H., Bradley, M. P., Hinchey, P., ... Dockendorff, T. C. (2010). Short- and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein. Journal of Neuroscience, 30(19), 6782-6792. https://doi.org/10.1523/JNEUROSCI.6369-09.2010
Banerjee, Paromita ; Schoenfeld, Brian P. ; Bell, Aaron J. ; Choi, Catherine H. ; Bradley, Michael P. ; Hinchey, Paul ; Kollaros, Maria ; Park, Jae H. ; McBride, Sean ; Dockendorff, Thomas C. / Short- and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein. In: Journal of Neuroscience. 2010 ; Vol. 30, No. 19. pp. 6782-6792.
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Banerjee, P, Schoenfeld, BP, Bell, AJ, Choi, CH, Bradley, MP, Hinchey, P, Kollaros, M, Park, JH, McBride, S & Dockendorff, TC 2010, 'Short- and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein', Journal of Neuroscience, vol. 30, no. 19, pp. 6782-6792. https://doi.org/10.1523/JNEUROSCI.6369-09.2010

Short- and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein. / Banerjee, Paromita; Schoenfeld, Brian P.; Bell, Aaron J.; Choi, Catherine H.; Bradley, Michael P.; Hinchey, Paul; Kollaros, Maria; Park, Jae H.; McBride, Sean; Dockendorff, Thomas C.

In: Journal of Neuroscience, Vol. 30, No. 19, 12.05.2010, p. 6782-6792.

Research output: Contribution to journalArticle

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AU - Bell, Aaron J.

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AU - Bradley, Michael P.

AU - Hinchey, Paul

AU - Kollaros, Maria

AU - Park, Jae H.

AU - McBride, Sean

AU - Dockendorff, Thomas C.

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