Short Communication: Low False Recent Rate of Limiting Antigen-Avidity Assay Combined with HIV-1 RNA Data in Botswana

Sikhulile Moyo, Kenanao P. Kotokwe, Terence Mohammed, Corretah Boleo, Lucy Mupfumi, Samuel Chishala, Lesedi Tsalaile, Hermann Bussmann, Simani Gaseitsiwe, Rosemary Musonda, Joseph Makhema, Marianna Baum, Richard Marlink, Susan Engelbrecht, Max Essex, Vladimir Novitsky

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Cross-sectional estimation of HIV incidence could misclassify some established or chronic HIV infections as recent. Usually long-term nonprogressors, elite and viremic controllers, and individuals on ART contribute to misclassification. Local data on the false recent rate (FRR) could minimize misclassification during estimation of HIV incidence. To improve monitoring of HIV incidence, we estimated local FRR in Botswana. A total of 1,036 specimens from individuals infected for at least 1.5-2 years were sampled between 2004 and 2009 and tested using the limiting antigen (LAg)-avidity assay using a cutoff of 1.5 normalized optical density units. The FRR was 0.97% (10/1,036; 95% confidence interval [CI] 0.46-1.77). Four samples had HIV-1 RNA >1,000 cps/ml, giving an adjusted FRR of 0.39% (4/1,036; 95% CI 0.11-0.99). A combination of LAg and HIV-1 RNA load data resulted in FRR below 1% in the Botswana population.

Original languageEnglish (US)
Pages (from-to)17-18
Number of pages2
JournalAIDS research and human retroviruses
Volume33
Issue number1
DOIs
StatePublished - Jan 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Virology
  • Immunology

Keywords

  • HIV incidence
  • HIV recency
  • cross-sectional incidence
  • false recency rate
  • limiting antigen assay

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  • Cite this

    Moyo, S., Kotokwe, K. P., Mohammed, T., Boleo, C., Mupfumi, L., Chishala, S., Tsalaile, L., Bussmann, H., Gaseitsiwe, S., Musonda, R., Makhema, J., Baum, M., Marlink, R., Engelbrecht, S., Essex, M., & Novitsky, V. (2017). Short Communication: Low False Recent Rate of Limiting Antigen-Avidity Assay Combined with HIV-1 RNA Data in Botswana. AIDS research and human retroviruses, 33(1), 17-18. https://doi.org/10.1089/aid.2016.0127