Signs of the 2009 influenza pandemic in the New York-Presbyterian hospital electronic health records

Hossein Khiabanian, Antony B. Holmes, Brendan J. Kelly, Mrinalini Gururaj, George Hripcsak, Raul Rabadan

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: In June of 2009, the World Health Organization declared the first influenza pandemic of the 21st century, and by July, New York City's New York-Presbyterian Hospital (NYPH) experienced a heavy burden of cases, attributable to a novel strain of the virus (H1N1pdm). Methods and Results: We present the signs in the NYPH electronic health records (EHR) that distinguished the 2009 pandemic from previous seasonal influenza outbreaks via various statistical analyses. These signs include (1) an increase in the number of patients diagnosed with influenza, (2) a preponderance of influenza diagnoses outside of the normal flu season, and (3) marked vaccine failure. The NYPH EHR also reveals distinct age distributions of patients affected by seasonal influenza and the pandemic strain, and via available longitudinal data, suggests that the two may be associated with distinct sets of comorbid conditions as well. In particular, we find significantly more pandemic flu patients with diagnoses associated with asthma and underlying lung disease. We further observe that the NYPH EHR is capable of tracking diseases at a resolution as high as particular zip codes in New York City. Conclusion: The NYPH EHR permits early detection of pandemic influenza and hypothesis generation via identification of those significantly associated illnesses. As data standards develop and databases expand, EHRs will contribute more and more to disease detection and the discovery of novel disease associations.

Original languageEnglish (US)
Article numbere12658
Pages (from-to)1-8
Number of pages8
JournalPLoS ONE
Volume5
Issue number9
DOIs
StatePublished - Nov 1 2010

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Electronic Health Records
Pandemics
pandemic
influenza
Human Influenza
electronics
Health
Pulmonary diseases
Viruses
Age Distribution
disease detection
Vaccines
Lung Diseases
Disease Outbreaks
asthma
World Health Organization
Asthma
Databases
respiratory tract diseases
vaccines

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Khiabanian, Hossein ; Holmes, Antony B. ; Kelly, Brendan J. ; Gururaj, Mrinalini ; Hripcsak, George ; Rabadan, Raul. / Signs of the 2009 influenza pandemic in the New York-Presbyterian hospital electronic health records. In: PLoS ONE. 2010 ; Vol. 5, No. 9. pp. 1-8.
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Signs of the 2009 influenza pandemic in the New York-Presbyterian hospital electronic health records. / Khiabanian, Hossein; Holmes, Antony B.; Kelly, Brendan J.; Gururaj, Mrinalini; Hripcsak, George; Rabadan, Raul.

In: PLoS ONE, Vol. 5, No. 9, e12658, 01.11.2010, p. 1-8.

Research output: Contribution to journalArticle

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