Sinonasal extramedullary plasmacytoma: A systematic review of 175 patients

Christine D'Aguillo, Resha S. Soni, Chirag Gordhan, James K. Liu, Soly Baredes, Jean Anderson Eloy

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background: This study reviews the published literature related to extramedullary sinonasal plasmacytomas. Clinical presentation, demographics, treatment, and outcomes of this uncommon disease are reported. Methods: A systematic review of studies for sinonasal plasmacytomas from 1950 to 2012 was conducted. A PubMed database search, both for articles related to this condition along with bibliographies of those selected articles, was performed. Articles were examined for patient data that reported disease outcome. Results: Sixty-seven journal articles were included in this analysis, comprising a total of 175 cases. Radiotherapy was the most common treatment modality, used in 89 cases, followed by a combination of surgery and radiotherapy, and surgery alone. A total of 71.8% of patients were alive after a median follow-up of 39 months, independent of treatment modality. A combination of radiotherapy and chemotherapy was rarely used but had the best treatment outcome, with 88.9% of patients (8/9 patients) alive. Of the 3 most common treatment modalities, a combination of radiotherapy and surgery had the most favorable outcomes. Sixteen patients (9.1%) converted to multiple myeloma, with the majority of these patients (75.0%) receiving radiotherapy alone as their treatment modality. Conclusion: This review contains the largest pool of sinonasal plasmacytoma patients to date and suggests aggressive radiotherapy is the most common treatment modality for this condition. Of the 3 most common treatment modalities, a combination of surgery and radiotherapy was shown to have the best survival outcomes.

Original languageEnglish (US)
Pages (from-to)156-163
Number of pages8
JournalInternational Forum of Allergy and Rhinology
Issue number2
StatePublished - Feb 2014

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Otorhinolaryngology


  • Chemotherapy
  • Extramedullary plasmacytoma
  • Nasal tumor
  • Plasmacytoma
  • Radiotherapy
  • Sinonasal plasmacytoma
  • Sinus tumor
  • Surgical management


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