Sleep and benzodiazepine receptor sub-types

W. B. Mendelson, J. V. Martin, M. Perils, R. Wagner

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


CL 218,872, which preferentially binds to benzodiazepine (BZ) type 1 receptors, and flurazepam, which is thought to bind to both types 1 and 2, were given alone and in combination to rats. CL 218,872 had little effect on sleep latency, but significantly increased total sleep time. As expected, flurazepam both shortened sleep latency and prolonged total sleep. Pretreatment with CL 218,872 had no effect on these alterations in sleep induced by flurazepam. The implications for possible significance of sub-typing of BZ receptors are discussed.

Original languageEnglish (US)
Pages (from-to)329-336
Number of pages8
JournalJournal of Neural Transmission
Issue number3-4
StatePublished - Sep 1987
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry


  • CL 218,872
  • Sleep
  • benzodiazepines


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