Sleep and benzodiazepine receptor sub-types

W. B. Mendelson; J. V. Martin; M. Perils; R. Wagner

doi:10.1007/BF01253607

Sleep and benzodiazepine receptor sub-types

W. B. Mendelson, J. V. Martin, M. Perils, R. Wagner

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

CL 218,872, which preferentially binds to benzodiazepine (BZ) type 1 receptors, and flurazepam, which is thought to bind to both types 1 and 2, were given alone and in combination to rats. CL 218,872 had little effect on sleep latency, but significantly increased total sleep time. As expected, flurazepam both shortened sleep latency and prolonged total sleep. Pretreatment with CL 218,872 had no effect on these alterations in sleep induced by flurazepam. The implications for possible significance of sub-typing of BZ receptors are discussed.

Original language	American English
Pages (from-to)	329-336
Number of pages	8
Journal	Journal of Neural Transmission
Volume	70
Issue number	3-4
DOIs	https://doi.org/10.1007/BF01253607
State	Published - Sep 1987
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

Keywords

CL 218,872
Sleep
benzodiazepines

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10.1007/BF01253607

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AU - Martin, J. V.

AU - Perils, M.

AU - Wagner, R.

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AB - CL 218,872, which preferentially binds to benzodiazepine (BZ) type 1 receptors, and flurazepam, which is thought to bind to both types 1 and 2, were given alone and in combination to rats. CL 218,872 had little effect on sleep latency, but significantly increased total sleep time. As expected, flurazepam both shortened sleep latency and prolonged total sleep. Pretreatment with CL 218,872 had no effect on these alterations in sleep induced by flurazepam. The implications for possible significance of sub-typing of BZ receptors are discussed.

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KW - benzodiazepines

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Sleep and benzodiazepine receptor sub-types

Abstract

ASJC Scopus subject areas

Keywords

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