Abstract
The effect of short term (8 weeks) sodium (Na+) depletion and its repletion on glomerular synthesis of heparan sulfate and urinary excretions of albumin, total protein, heparan sulfate, Na+ and potassium (K+) was studied in spontaneous hypertensive rats (SHR) and their control normotensive Wistar-Kyoto rats (WKY). Na+ depletion in SHRs significantly increased the synthesis of glomerular heparan sulfate and decreased urinary excretions of albumin, Na+ and heparan sulfate when compared with the Na+ repleted group. In WKY rats, Na+ depletion did not cause any of the above changes. These data suggest that Na+ depletion prevents the urinary loss of protein through preservation of glomerular heparan sulfate only in SHRs.
| Original language | American English |
|---|---|
| Pages (from-to) | 115-124 |
| Number of pages | 10 |
| Journal | Research Communications in Molecular Pathology and Pharmacology |
| Volume | 90 |
| Issue number | 1 |
| State | Published - 1995 |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology