Sodium glomerulopathy: Tubuloglomerular feedback and renal injury in African Americans

Abraham Aviv, Norman K. Hollenberg, Alan B. Weder

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

African Americans are prone to develop not only essential hypertension but also progressive renal injury. We present a simple model to explain salt-induced renal injury (sodium glomerulopathy) in African Americans, the central features of which are the tubuloglomerular feedback and the balance/imbalance between the vascular tones of the afferent and efferent glomerular arterioles. We propose that in African Americans, habitual consumption of high salt causes chronic intermittent tubular hyperperfusion of the macula densa, resulting in a rightward and upward resetting of the operating point for the tubuloglomerular feedback. The resetting of the operating point causes an imbalance between the vascular tones of the afferent/efferent arterioles, a rise in the glomerular capillary hydraulic pressure, and consequent hyperfiltration. Increased susceptibility to glomerular hyperfiltration of African Americans on a high salt intake may explain their proclivity to progressive renal injury associated with essential hypertension.

Original languageEnglish (US)
Pages (from-to)361-368
Number of pages8
JournalKidney International
Volume65
Issue number2
DOIs
StatePublished - Feb 2004

All Science Journal Classification (ASJC) codes

  • Nephrology

Keywords

  • Glomerular filtration
  • Hypertension
  • Kidney
  • Kidney failure
  • Salt
  • Sodium

Fingerprint Dive into the research topics of 'Sodium glomerulopathy: Tubuloglomerular feedback and renal injury in African Americans'. Together they form a unique fingerprint.

  • Cite this