TY - JOUR
T1 - Source localization of event-related potentials to pitch change mapped onto age-appropriate MRIs at 6months of age
AU - Hämäläinen, Jarmo A.
AU - Ortiz-Mantilla, Silvia
AU - Benasich, April A.
N1 - Funding Information: We would like to thank Cecylia Chojnowska for ERP data processing, Maria del Mar Quiroga for her help with MRI measures, Jonathan Kaiser for creating the average MRI template, and all the families that participated in the study. The study was supported by the Santa Fe Institute Consortium , the Elizabeth H. Solomon Center for Neurodevelopmental Research , and by grants to AAB from NSF #SBE-0542013 (to the Temporal Dynamics Learning Center) and to JAH from the Academy of Finland ( #127277 ).
PY - 2011/2/1
Y1 - 2011/2/1
N2 - Auditory event-related potentials (ERPs) have been used to understand how the brain processes auditory input, and to track developmental change in sensory systems. Localizing ERP generators can provide invaluable insights into how and where auditory information is processed. However, age-appropriate infant brain templates have not been available to aid such developmental mapping. In this study, auditory change detection responses of brain ERPs were examined in 6-month-old infants using discrete and distributed source localization methods mapped onto age-appropriate magnetic resonance images. Infants received a passive oddball paradigm using fast-rate non-linguistic auditory stimuli (tone doublets) with the deviant incorporating a pitch change for the second tone. Data was processed using two different high-pass filters. When a 0.5. Hz filter was used, the response to the pitch change was a large frontocentral positive component. When a 3. Hz filter was applied, two temporally consecutive components associated with change detection were seen: one with negative voltage, and another with positive voltage over frontocentral areas. Both components were localized close to the auditory cortex with an additional source near to the anterior cingulate cortex. The sources for the negative response had a more tangential orientation relative to the supratemporal plane compared to the positive response, which showed a more lateral, oblique orientation. The results described here suggest that at 6. months of age infants generate similar response patterns and use analogous cortical areas to that of adults to detect changes in the auditory environment. Moreover, the source locations and orientations, together with waveform topography and morphology provide evidence in infants for feature-specific change detection followed by involuntary switching of attention.
AB - Auditory event-related potentials (ERPs) have been used to understand how the brain processes auditory input, and to track developmental change in sensory systems. Localizing ERP generators can provide invaluable insights into how and where auditory information is processed. However, age-appropriate infant brain templates have not been available to aid such developmental mapping. In this study, auditory change detection responses of brain ERPs were examined in 6-month-old infants using discrete and distributed source localization methods mapped onto age-appropriate magnetic resonance images. Infants received a passive oddball paradigm using fast-rate non-linguistic auditory stimuli (tone doublets) with the deviant incorporating a pitch change for the second tone. Data was processed using two different high-pass filters. When a 0.5. Hz filter was used, the response to the pitch change was a large frontocentral positive component. When a 3. Hz filter was applied, two temporally consecutive components associated with change detection were seen: one with negative voltage, and another with positive voltage over frontocentral areas. Both components were localized close to the auditory cortex with an additional source near to the anterior cingulate cortex. The sources for the negative response had a more tangential orientation relative to the supratemporal plane compared to the positive response, which showed a more lateral, oblique orientation. The results described here suggest that at 6. months of age infants generate similar response patterns and use analogous cortical areas to that of adults to detect changes in the auditory environment. Moreover, the source locations and orientations, together with waveform topography and morphology provide evidence in infants for feature-specific change detection followed by involuntary switching of attention.
KW - Auditory
KW - Change detection
KW - Event-related potentials
KW - Infants
KW - Mismatch response
KW - Source localization
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U2 - 10.1016/j.neuroimage.2010.10.016
DO - 10.1016/j.neuroimage.2010.10.016
M3 - Article
C2 - 20951812
SN - 1053-8119
VL - 54
SP - 1910
EP - 1918
JO - Neuroimage
JF - Neuroimage
IS - 3
ER -