Abstract
Multivalent associative proteins with strong complementary interactions play a crucial role in phase separation of intracellular liquid condensates. We study the internal dynamics of such "bond-network"condensates comprising two complementary proteins via scaling analysis and molecular dynamics. We find that when stoichiometry is balanced, relaxation slows down dramatically due to a scarcity of alternative binding partners following bond breakage. This microscopic slow-down strongly affects the bulk diffusivity, viscosity, and mixing, which provides a means to experimentally test this prediction.
| Original language | American English |
|---|---|
| Article number | A82 |
| Journal | Physical review letters |
| Volume | 128 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 21 2022 |
ASJC Scopus subject areas
- General Physics and Astronomy