Abstract

Effective cancer therapy remains a challenge despite recent advances in the identification of novel targets. A major limitation of most chemotherapeutic drugs is their systemic toxicity and the efficacy of cancer treatments is, by and large, determined by the ability to balance their benefits against their toxicity. Targeted treatments for cancer, especially those that target the tumor vasculature, have provided promising antitumor results with minimal systemic toxicity. To date significant progress has been made in developing a variety of delivery systems to target cancer and its vasculature ranging from isolated limb and organ perfusion to tumor targeted biological and nonbiological vectors.

Original languageEnglish (US)
Pages (from-to)135-152
Number of pages18
JournalAdvances in Genetics
Volume69
Issue numberC
DOIs
StatePublished - Jan 1 2010

Fingerprint

Neoplasms
Therapeutics
Extremities
Perfusion
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

@article{61a192d2b9e74508b7a589800a6b8bed,
title = "Strategies for Targeting Tumors and Tumor Vasculature for Cancer Therapy",
abstract = "Effective cancer therapy remains a challenge despite recent advances in the identification of novel targets. A major limitation of most chemotherapeutic drugs is their systemic toxicity and the efficacy of cancer treatments is, by and large, determined by the ability to balance their benefits against their toxicity. Targeted treatments for cancer, especially those that target the tumor vasculature, have provided promising antitumor results with minimal systemic toxicity. To date significant progress has been made in developing a variety of delivery systems to target cancer and its vasculature ranging from isolated limb and organ perfusion to tumor targeted biological and nonbiological vectors.",
author = "Libutti, {Steven K.}",
year = "2010",
month = "1",
day = "1",
doi = "https://doi.org/10.1016/S0065-2660(10)69015-3",
language = "English (US)",
volume = "69",
pages = "135--152",
journal = "Advances in Genetics",
issn = "0065-2660",
publisher = "Academic Press Inc.",
number = "C",

}

Strategies for Targeting Tumors and Tumor Vasculature for Cancer Therapy. / Libutti, Steven K.

In: Advances in Genetics, Vol. 69, No. C, 01.01.2010, p. 135-152.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Strategies for Targeting Tumors and Tumor Vasculature for Cancer Therapy

AU - Libutti, Steven K.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Effective cancer therapy remains a challenge despite recent advances in the identification of novel targets. A major limitation of most chemotherapeutic drugs is their systemic toxicity and the efficacy of cancer treatments is, by and large, determined by the ability to balance their benefits against their toxicity. Targeted treatments for cancer, especially those that target the tumor vasculature, have provided promising antitumor results with minimal systemic toxicity. To date significant progress has been made in developing a variety of delivery systems to target cancer and its vasculature ranging from isolated limb and organ perfusion to tumor targeted biological and nonbiological vectors.

AB - Effective cancer therapy remains a challenge despite recent advances in the identification of novel targets. A major limitation of most chemotherapeutic drugs is their systemic toxicity and the efficacy of cancer treatments is, by and large, determined by the ability to balance their benefits against their toxicity. Targeted treatments for cancer, especially those that target the tumor vasculature, have provided promising antitumor results with minimal systemic toxicity. To date significant progress has been made in developing a variety of delivery systems to target cancer and its vasculature ranging from isolated limb and organ perfusion to tumor targeted biological and nonbiological vectors.

UR - http://www.scopus.com/inward/record.url?scp=77956149322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956149322&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/S0065-2660(10)69015-3

DO - https://doi.org/10.1016/S0065-2660(10)69015-3

M3 - Article

C2 - 20807606

VL - 69

SP - 135

EP - 152

JO - Advances in Genetics

JF - Advances in Genetics

SN - 0065-2660

IS - C

ER -