Stress-induced suppression of immunity in adrenalectomized rats

Steven E. Keller, Jay M. Weiss, Steven J. Schleifer, Neil E. Miller, Marvin Stein

Research output: Contribution to journalArticle

333 Scopus citations

Abstract

Stress-induced suppression of lymphocyte stimulation by phytohemag glutinin was demonstrated in isolated lymphocytes and in cultures of whole blood from adrenalectomized rats. The results demonstrate that corticosteroid independent mechanisms participate in the suppression of lymphocyte function by Stressors. Stress-induced lymphopenia, however, was found to be adrenal dependent, indicating that the modulation of immunity by stress is complex and multidetermined.

Original languageEnglish (US)
Pages (from-to)1301-1304
Number of pages4
JournalScience
Volume221
Issue number4617
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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