Stretch-activated ion channels in cultured mesangial cells

William Craelius, Nabil El-Sherif, Carlos E. Palant

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Membrane stretch, delivered by negative pressures in cell-attached patch pipets, activated single-channel ionic currents in cultured mesangial cells. Channel opening probabilities were directly related to degree of suction, with threshold for activation being 5-10 mm Hg. The stretch-activated channels were permeable to Na+, K+, as well as Cl-, having conductances averaging 62 ± 17 pS. These channels may represent a cellular mechano-reflex in mesangial cells.

Original languageEnglish (US)
Pages (from-to)516-521
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume159
Issue number2
DOIs
StatePublished - Mar 15 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biophysics
  • Biochemistry
  • Cell Biology

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