Membrane stretch, delivered by negative pressures in cell-attached patch pipets, activated single-channel ionic currents in cultured mesangial cells. Channel opening probabilities were directly related to degree of suction, with threshold for activation being 5-10 mm Hg. The stretch-activated channels were permeable to Na+, K+, as well as Cl-, having conductances averaging 62 ± 17 pS. These channels may represent a cellular mechano-reflex in mesangial cells.
|Original language||English (US)|
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Mar 15 1989|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology