Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandem mass spectrometry

Xi Shao, Xiaoxin Chen, Vladimir Badmaev, Chi Tang Ho, Shengmin Sang

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Pterostilbene, the dimethoxy derivative of resveratrol, has drawn much attention recently due to its potential beneficial health effects. The metabolic fate of pterostilbene, however, is not well understood. In the present study, we identified nine novel mouse urinary pterostilbene metabolites, pterostilbene glucuronide, pterostilbene sulfate, mono-demethylated pterostilbene glucuronide, mono-demethylated pterostilbene sulfate, mono-hydroxylated pterostilbene, mono-hydroxylated pterostilbene glucuronide, mono-hydroxylated pterostilbene sulfate, and mono-hydroxylated pterostilbene glucuronide sulfate, using liquid chromatography/atmospheric pressure chemical ionization and electrospray ionization tandem mass spectrometry. The structures of these metabolites were confirmed by analyzing the MSn (n=1-3) spectra. To our knowledge, this is the first report of the identification of urinary metabolites of pterostilbene in mice.

Original languageEnglish (US)
Pages (from-to)1770-1778
Number of pages9
JournalRapid Communications in Mass Spectrometry
Volume24
Issue number12
DOIs
StatePublished - Jun 2010

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry

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