Studies on 1-O-acetylbritannilactone and its derivative, (2-O-butyloxime-3-phenyl)-propionyl-1-O-acetylbritannilactone ester

Shouxin Liu, He Liu, Weiying Yan, Li Zhang, Naisheng Bai, Chi Tang Ho

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The crystal structures of 1-O-acetylbritannilactone 6 isolated from Inula britannica, and its derivative (2-O-butyloxime-3-phenyl) propionyl 1-O-acetylbritannilactone ester 7 are reported. The structure of synthesized derivative 7 was established by spectroscopic methods. Both compounds inhibited the growth of human HL-60, Bel-7402 cell lines and compound 7 had the stronger cytotoxic activity.

Original languageEnglish (US)
Pages (from-to)1101-1104
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number5
DOIs
StatePublished - Mar 8 2004

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Molecular Medicine
  • Molecular Biology
  • Biochemistry
  • Clinical Biochemistry
  • Pharmaceutical Science
  • Organic Chemistry

Keywords

  • (2-O-butyloxime-1- phenyl) propionic acid derivative
  • Cytotoxicity
  • Inula britannica
  • Sesquiterpene lactone
  • X-ray crystal structures

Fingerprint

Dive into the research topics of 'Studies on 1-O-acetylbritannilactone and its derivative, (2-O-butyloxime-3-phenyl)-propionyl-1-O-acetylbritannilactone ester'. Together they form a unique fingerprint.

Cite this