Substance craving changes in university students receiving heart rate variability biofeedback: A longitudinal multilevel modeling approach

Nour Alayan, David Eddie, Lucille Eller, Marsha E. Bates, Dennis P. Carmody

Research output: Contribution to journalArticle

3 Scopus citations


Background: Previously published findings from a study of university students living in substance use disorder (SUD)recovery housing showed an eight-session heart rate variability biofeedback (HRVB)intervention significantly reduced craving. That study, however, uncovered pronounced inter-participant variability in craving change patterns through the course of HRVB that warranted further exploration. The purpose of the current investigation was to examine how within- and between-person factors may have differentially influenced craving changes. Methods: A longitudinal multilevel modeling approach was used with time at level-1 nested within persons at level-2. Multilevel models of change were estimated to model craving trajectories and predictor relationships over time as a function of age, sex, length of abstinence, daily HRVB practice, anxiety, depression, and stress. Results: A quadratic pattern of craving reductions was found, indicating that craving reductions accelerated over time for some participants. Daily HRVB practice of >12 min and older age significantly enhanced craving reductions over time. Increases in depressive symptoms attenuated the effects of HRVB on craving. The other predictors were not significantly associated with craving in this study. The true R2 for the final model indicated that 20.5% of the variance in craving was explained by older age, daily HRVB >12 min, and within-person changes in depression. Conclusions: HRVB shows promise as an accessible, scalable, and cost-effective complementary anti-craving intervention. Healthcare providers may help persons recovering from SUD to better manage substance craving by the routine and strategic use of HRVB practice.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalAddictive Behaviors
StatePublished - Oct 2019

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Clinical Psychology
  • Medicine (miscellaneous)
  • Toxicology


  • Craving
  • Heart rate variability biofeedback
  • Longitudinal
  • Multilevel modeling
  • Substance use disorder

Fingerprint Dive into the research topics of 'Substance craving changes in university students receiving heart rate variability biofeedback: A longitudinal multilevel modeling approach'. Together they form a unique fingerprint.

  • Cite this