Successful aging in a 70-year-old man with down syndrome: A case study

Sharon J. Krinsky-McHale; Darlynne A. Devenny; Hong Gu; Edmund C. Jenkins; Phyllis Kittler; Vundavalli V. Murty; Nicole Schupf; Luigi Scotto; Benjamin Tycko; Tiina K. Urv; Lingling Ye; Warren B. Zigman; Wayne Silverman

doi:10.1352/2008.46:215-228

Successful aging in a 70-year-old man with down syndrome: A case study

Sharon J. Krinsky-McHale
, Darlynne A. Devenny
, Hong Gu
, Edmund C. Jenkins
, Phyllis Kittler
, Vundavalli V. Murty
, Nicole Schupf
, Luigi Scotto
, Benjamin Tycko
, Tiina K. Urv
, Lingling Ye
, Warren B. Zigman
, Wayne Silverman

Center for Discovery and Innovation

Hackensack Meridian School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The authors present a case study of a 70-year-old man with Down syndrome ("Mr. C.") who they followed for 16 years and who does not exhibit declines in cognitive or functional capacities indicative of dementia, despite having well-documented, complete trisomy 21. The authors describe the age-associated changes that occurred over 16 years as well as provide detailed information regarding Mr. C.'s health and genetic status. To further emphasize Mr. C.'s successful aging, the authors compared his longitudinal performance profile with that of 2 peers of comparable level of intellectual functioning: 1 similar-aged man with clinical Alzheimer's disease and a younger man who was healthy. The authors present potential explanations for the phenotypic variability observed in individuals with Down syndrome.

Original language	English
Pages (from-to)	215-228
Number of pages	14
Journal	Intellectual and Developmental Disabilities
Volume	46
Issue number	3
DOIs	https://doi.org/10.1352/2008.46:215-228
State	Published - Jun 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Education
Developmental and Educational Psychology
Community and Home Care
Psychiatry and Mental health

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Cite this

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title = "Successful aging in a 70-year-old man with down syndrome: A case study",

abstract = "The authors present a case study of a 70-year-old man with Down syndrome ({"}Mr. C.{"}) who they followed for 16 years and who does not exhibit declines in cognitive or functional capacities indicative of dementia, despite having well-documented, complete trisomy 21. The authors describe the age-associated changes that occurred over 16 years as well as provide detailed information regarding Mr. C.'s health and genetic status. To further emphasize Mr. C.'s successful aging, the authors compared his longitudinal performance profile with that of 2 peers of comparable level of intellectual functioning: 1 similar-aged man with clinical Alzheimer's disease and a younger man who was healthy. The authors present potential explanations for the phenotypic variability observed in individuals with Down syndrome.",

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AU - Krinsky-McHale, Sharon J.

AU - Devenny, Darlynne A.

AU - Gu, Hong

AU - Jenkins, Edmund C.

AU - Kittler, Phyllis

AU - Murty, Vundavalli V.

AU - Schupf, Nicole

AU - Scotto, Luigi

AU - Tycko, Benjamin

AU - Urv, Tiina K.

AU - Ye, Lingling

AU - Zigman, Warren B.

AU - Silverman, Wayne

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AB - The authors present a case study of a 70-year-old man with Down syndrome ("Mr. C.") who they followed for 16 years and who does not exhibit declines in cognitive or functional capacities indicative of dementia, despite having well-documented, complete trisomy 21. The authors describe the age-associated changes that occurred over 16 years as well as provide detailed information regarding Mr. C.'s health and genetic status. To further emphasize Mr. C.'s successful aging, the authors compared his longitudinal performance profile with that of 2 peers of comparable level of intellectual functioning: 1 similar-aged man with clinical Alzheimer's disease and a younger man who was healthy. The authors present potential explanations for the phenotypic variability observed in individuals with Down syndrome.

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Successful aging in a 70-year-old man with down syndrome: A case study

Abstract

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ASJC Scopus subject areas

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