Synapsis, double-strand breaks, and domains of crossover control in drosophila females

Sonam Mehrotra, R. Scott Hawley, Kim S. McKim

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

Drosophila is an attractive model system in which powerful tools in genetics and cytology can be used to identify and characterize the genes required for meiotic recombination. This article reviews recent developments in understanding how pairing and synapsis proceed in the absence of double-strand breaks (DSBs), the relationship of DSB formation to synapsis, how crossovers are determined and formed, and the role that chromosome structure, including specialized sites, plays in regulating DSB formation and repair.

Original languageAmerican English
Title of host publicationRecombination and Meiosis
Subtitle of host publicationCrossing-Over and Disjunction
EditorsRichard Egel, Dirk-Henner Lankenau
Pages125-151
Number of pages27
DOIs
StatePublished - 2008

Publication series

NameGenome Dynamics and Stability
Volume2

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint

Dive into the research topics of 'Synapsis, double-strand breaks, and domains of crossover control in drosophila females'. Together they form a unique fingerprint.

Cite this