Synthesis and characterization of pseudopoly(amino acids). New polymers for medical applications

Research output: Contribution to journalConference article

3 Citations (Scopus)

Abstract

An important obstacle to the clinical use of degradable polymers is the possible toxicity of the polymer degradation products. We have recently prepared a series of poly(amino acids) in which we replaced conventional peptide bonds in the polymer backbone by a variety of 'non-amide' linkages. The resulting materials can best be regarded as 'pseudo'-poly(amino acids). Preliminary results indicate that 'pseudo'-poly(amino acids) tend to retain the low toxicity of the amino acids, while at the same time exhibiting significantly improved polymer engineering properties. Polymerization reactions involving the side chains of naturally occurring amino acids proceed readily and lead to the formation of linear polymers of high molecular weight. So far, four new pseudo-poly(amino acids) have been prepared, which all show significantly improved engineering properties relative to the corresponding, conventional poly(amino acids).

Original languageEnglish (US)
Pages (from-to)178-179
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume31
Issue number2
StatePublished - Aug 1 1990
EventPapers presented at the Washington, DC Meeting 1990 of the ACS, Division of Polymer Chemistry - Washington, DC, USA
Duration: Aug 26 1990Aug 31 1990

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Medical applications
Amino acids
Polymers
Amino Acids
Toxicity
Peptides
Molecular weight
Polymerization
Degradation

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Polymers and Plastics
  • Materials Science(all)

Cite this

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title = "Synthesis and characterization of pseudopoly(amino acids). New polymers for medical applications",
abstract = "An important obstacle to the clinical use of degradable polymers is the possible toxicity of the polymer degradation products. We have recently prepared a series of poly(amino acids) in which we replaced conventional peptide bonds in the polymer backbone by a variety of 'non-amide' linkages. The resulting materials can best be regarded as 'pseudo'-poly(amino acids). Preliminary results indicate that 'pseudo'-poly(amino acids) tend to retain the low toxicity of the amino acids, while at the same time exhibiting significantly improved polymer engineering properties. Polymerization reactions involving the side chains of naturally occurring amino acids proceed readily and lead to the formation of linear polymers of high molecular weight. So far, four new pseudo-poly(amino acids) have been prepared, which all show significantly improved engineering properties relative to the corresponding, conventional poly(amino acids).",
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T1 - Synthesis and characterization of pseudopoly(amino acids). New polymers for medical applications

AU - Kohn, Joachim

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N2 - An important obstacle to the clinical use of degradable polymers is the possible toxicity of the polymer degradation products. We have recently prepared a series of poly(amino acids) in which we replaced conventional peptide bonds in the polymer backbone by a variety of 'non-amide' linkages. The resulting materials can best be regarded as 'pseudo'-poly(amino acids). Preliminary results indicate that 'pseudo'-poly(amino acids) tend to retain the low toxicity of the amino acids, while at the same time exhibiting significantly improved polymer engineering properties. Polymerization reactions involving the side chains of naturally occurring amino acids proceed readily and lead to the formation of linear polymers of high molecular weight. So far, four new pseudo-poly(amino acids) have been prepared, which all show significantly improved engineering properties relative to the corresponding, conventional poly(amino acids).

AB - An important obstacle to the clinical use of degradable polymers is the possible toxicity of the polymer degradation products. We have recently prepared a series of poly(amino acids) in which we replaced conventional peptide bonds in the polymer backbone by a variety of 'non-amide' linkages. The resulting materials can best be regarded as 'pseudo'-poly(amino acids). Preliminary results indicate that 'pseudo'-poly(amino acids) tend to retain the low toxicity of the amino acids, while at the same time exhibiting significantly improved polymer engineering properties. Polymerization reactions involving the side chains of naturally occurring amino acids proceed readily and lead to the formation of linear polymers of high molecular weight. So far, four new pseudo-poly(amino acids) have been prepared, which all show significantly improved engineering properties relative to the corresponding, conventional poly(amino acids).

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M3 - Conference article

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SP - 178

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JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

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