Synthesis of 1H-2,3-dihydropyrrolizine derivatives as precursors of bifunctional alkylating agents

TY - JOUR

T1 - Synthesis of 1H-2,3-dihydropyrrolizine derivatives as precursors of bifunctional alkylating agents

AU - Rajaraman, Shanthi

AU - Jimenez, Leslie S.

N1 - Funding Information: We gratefully acknowledge the National Science Foundation (CHE-0074836), the Charles and Johanna Busch Memorial Fund, and Schering-Plough Research Institute, Kenilworth, NJ for support of this research.

PY - 2002/12/23

Y1 - 2002/12/23

N2 - Two 1H-2,3-dihydropyrrolizine derivatives bearing a nitro group at the 6 position have been synthesized and an improved method for nitrating pyrroles using potassium nitrate in trifluoroacetic acid was developed. An efficient, two-step synthesis of the butterfly pheromone, Danaidone, was also developed with an overall 33% yield.

AB - Two 1H-2,3-dihydropyrrolizine derivatives bearing a nitro group at the 6 position have been synthesized and an improved method for nitrating pyrroles using potassium nitrate in trifluoroacetic acid was developed. An efficient, two-step synthesis of the butterfly pheromone, Danaidone, was also developed with an overall 33% yield.

KW - Antitumor agents

KW - Bifunctional alkylating agents

KW - Dihydropyrrolizine

UR - http://www.scopus.com/inward/record.url?scp=0037164635&partnerID=8YFLogxK

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U2 - https://doi.org/10.1016/S0040-4020(02)01419-9

DO - https://doi.org/10.1016/S0040-4020(02)01419-9

M3 - Article

SN - 0040-4020

VL - 58

SP - 10407

EP - 10412

JO - Tetrahedron

JF - Tetrahedron

IS - 52

ER -