Synthetic approaches to 4,8-dimethyl-4′- (N-pyridiniummethyl)-4′,5′-dihydropsoralens and their activity against PAM 212 keratinocytes

TY - JOUR

T1 - Synthetic approaches to 4,8-dimethyl-4′- (N-pyridiniummethyl)-4′,5′-dihydropsoralens and their activity against PAM 212 keratinocytes

AU - Whittemore, Marilyn

AU - Heindel, Ned

AU - Guillon, Christophe

AU - McNeel, Thomas

AU - Rapp, Robert

AU - Mariano, Thomas

AU - Heck, Diane

AU - Laskin, Jeffrey

PY - 2001/6/1

Y1 - 2001/6/1

N2 - Synthetic approaches to novel 4,8-dimethyl-4′-halomethyl-4′,5′-dihydropsoralens as synthetic precursors to 4,8-dimethyl-4′-(N-pyridiniummethyl)-4′,5′-dihydropsoralens are described. The compounds are potential therapeutic agents for improved psoralen ultraviolet radiation therapy with reduced mutagenicity.

AB - Synthetic approaches to novel 4,8-dimethyl-4′-halomethyl-4′,5′-dihydropsoralens as synthetic precursors to 4,8-dimethyl-4′-(N-pyridiniummethyl)-4′,5′-dihydropsoralens are described. The compounds are potential therapeutic agents for improved psoralen ultraviolet radiation therapy with reduced mutagenicity.

UR - https://www.scopus.com/pages/publications/0035363859

UR - https://www.scopus.com/pages/publications/0035363859#tab=citedBy

U2 - 10.3987/COM-01-9197

DO - 10.3987/COM-01-9197

M3 - Article

SN - 0385-5414

VL - 55

SP - 1081

EP - 1093

JO - Heterocycles

JF - Heterocycles

IS - 6

ER -