TDP-43 and frontotemporal dementia

William T. Hu, Murray Grossman

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


TAR DNA-binding protein of about 43 kDa (TDP-43) is the main ubiquitinated peptide in tau-negative frontotemporal lobar degeneration (FTLD). TDP-43 is typically a nuclear protein, and its aggregation and cytoplasmic translocation are thought to represent major steps in the pathogenesis of FTLD due to TDP-43 proteinopathy (FTLD-TDP). Certain clinical syndromes of frontotemporal dementia are preferentially associated with pathologic findings of FTLD-TDP, and TDP-43 pathology represents the connection between FTLD-TDP and amyotrophic lateral sclerosis. Recent advances in clinical, genetic, and pathologic studies of FTLD-TDP and amyotrophic lateral sclerosis have shed light on the potentially pathogenic role of TDP-43 and identified TDP-43 itself as a candidate biomarker for antemortem diagnosis of FTLD-TDP.

Original languageEnglish (US)
Pages (from-to)353-358
Number of pages6
JournalCurrent Neurology and Neuroscience Reports
Issue number5
StatePublished - 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neuroscience(all)


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