Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia

Edmund C. Jenkins, Milen T. Velinov, Lingling Ye, Hong Gu, Shuyun Li, Edmund C. Jenkins, Susan Sklower Brooks, Deborah Pang, Darlynne A. Devenny, Warren B. Zigman, Nicole Schupf, Wayne P. Silverman

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Telomere shortening has been recently correlated with Alzheimer's disease status. Therefore, we hypothesized that a possible association might exist for adults with Down syndrome (DS). Using blind, quantitative telomere protein nucleic acid FISH analyses of metaphase and interphase preparations from 18 age-matched trisomy 21 female study participants with and without dementia, we have observed increased telomere shortening in adults with DS and dementia (p < .01). From this initial study, we conclude that telomere shortening is associated with dementia in this high-risk population and suggest that additional research may show that telomere shortening may be a biological marker of dementia status.

Original languageEnglish (US)
Pages (from-to)941-945
Number of pages5
JournalNeurobiology of Aging
Volume27
Issue number7
DOIs
StatePublished - Jul 2006

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Aging
  • Neuroscience(all)
  • Developmental Biology

Keywords

  • Dementia
  • Down syndrome
  • FISH
  • Interphase
  • Metaphase
  • Telomere shortening

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