Temporal association of cannabis use with symptoms in individuals at clinical high risk for psychosis

Cheryl M. Corcoran, David Kimhy, Arielle Stanford, Shamir Khan, Julie Walsh, Judy Thompson, Scott Schobel, Jill Harkavy-Friedman, Ray Goetz, Tiziano Colibazzi, Victoria Cressman, Dolores Malaspina

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Background: Cannabis use is reported to increase the risk for psychosis, but no prospective study has longitudinally examined drug use and symptoms concurrently in clinical high risk cases. Method: We prospectively followed for up to 2 years 32 cases who met research criteria for prodromal psychosis to examine the relationship between substance use and clinical measures. Results: Cases with a baseline history of cannabis use (41%) were older, but did not differ in clinical measures. Longitudinal assessments showed these cases had significantly more perceptual disturbances and worse functioning during epochs of increased cannabis use that were unexplained by concurrent use of other drugs or medications. Conclusions: These data demonstrate that cannabis use may be a risk factor for the exacerbation of subthreshold psychotic symptoms, specifically perceptual disturbances, in high risk cases.

Original languageEnglish (US)
Pages (from-to)286-293
Number of pages8
JournalSchizophrenia Research
Volume106
Issue number2-3
DOIs
StatePublished - Dec 2008
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Keywords

  • Cannabis
  • Longitudinal
  • Prodrome
  • Psychosis
  • Risk

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