Temporal regulation of gene expression in adipocyte differentiation

Jeffrey J. Martino; Suzie Chen

doi:https://doi.org/10.1016/0014-5793(96)00254-2

Temporal regulation of gene expression in adipocyte differentiation

Jeffrey J. Martino, Suzie Chen

Pharm - Chemical Biology

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Abstract

Cells usually become 'committed' to differentiate long before any actual morphological change is apparent. In one model commitment is a decision which corresponds to the expression of a control gene, while differentiation is the ultimate consequence of that decision. We have been studying adipocyte commitment and differentiation at the molecular level. Earlier we showed that the introduction of a specific DNA sequence into 'uncommitted' cells renders those cells committed to differentiate into adipocytes. Here we report temporal regulation of the expression of this DNA sequence; furthermore, we show that this RNA is in the non-polyA⁺ fraction of total cellular RNA. These data suggest that coordinate regulation of this and other genes is important in promoting differentiation.

Original language	English (US)
Pages (from-to)	1-3
Number of pages	3
Journal	FEBS Letters
Volume	385
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(96)00254-2
State	Published - Apr 29 1996

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Keywords

Adipocyte differentiation
RNA expression
Temporal regulation

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https://doi.org/10.1016/0014-5793(96)00254-2

Cite this

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title = "Temporal regulation of gene expression in adipocyte differentiation",

abstract = "Cells usually become 'committed' to differentiate long before any actual morphological change is apparent. In one model commitment is a decision which corresponds to the expression of a control gene, while differentiation is the ultimate consequence of that decision. We have been studying adipocyte commitment and differentiation at the molecular level. Earlier we showed that the introduction of a specific DNA sequence into 'uncommitted' cells renders those cells committed to differentiate into adipocytes. Here we report temporal regulation of the expression of this DNA sequence; furthermore, we show that this RNA is in the non-polyA+ fraction of total cellular RNA. These data suggest that coordinate regulation of this and other genes is important in promoting differentiation.",

keywords = "Adipocyte differentiation, RNA expression, Temporal regulation",

author = "Martino, {Jeffrey J.} and Suzie Chen",

note = "Funding Information: Acknowledgements: This work was supported by USDA (9404381) and New York Obesity Research Center. We are indebted to Drs. A. Conney, Pollack, Teicher, and Wise for discussion and criticism.",

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AU - Martino, Jeffrey J.

AU - Chen, Suzie

N1 - Funding Information: Acknowledgements: This work was supported by USDA (9404381) and New York Obesity Research Center. We are indebted to Drs. A. Conney, Pollack, Teicher, and Wise for discussion and criticism.

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N2 - Cells usually become 'committed' to differentiate long before any actual morphological change is apparent. In one model commitment is a decision which corresponds to the expression of a control gene, while differentiation is the ultimate consequence of that decision. We have been studying adipocyte commitment and differentiation at the molecular level. Earlier we showed that the introduction of a specific DNA sequence into 'uncommitted' cells renders those cells committed to differentiate into adipocytes. Here we report temporal regulation of the expression of this DNA sequence; furthermore, we show that this RNA is in the non-polyA+ fraction of total cellular RNA. These data suggest that coordinate regulation of this and other genes is important in promoting differentiation.

AB - Cells usually become 'committed' to differentiate long before any actual morphological change is apparent. In one model commitment is a decision which corresponds to the expression of a control gene, while differentiation is the ultimate consequence of that decision. We have been studying adipocyte commitment and differentiation at the molecular level. Earlier we showed that the introduction of a specific DNA sequence into 'uncommitted' cells renders those cells committed to differentiate into adipocytes. Here we report temporal regulation of the expression of this DNA sequence; furthermore, we show that this RNA is in the non-polyA+ fraction of total cellular RNA. These data suggest that coordinate regulation of this and other genes is important in promoting differentiation.

KW - Adipocyte differentiation

KW - RNA expression

KW - Temporal regulation

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Temporal regulation of gene expression in adipocyte differentiation

Abstract

ASJC Scopus subject areas

Keywords

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