Temporal regulation of gene expression in adipocyte differentiation

Jeffrey J. Martino, Suzie Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Cells usually become 'committed' to differentiate long before any actual morphological change is apparent. In one model commitment is a decision which corresponds to the expression of a control gene, while differentiation is the ultimate consequence of that decision. We have been studying adipocyte commitment and differentiation at the molecular level. Earlier we showed that the introduction of a specific DNA sequence into 'uncommitted' cells renders those cells committed to differentiate into adipocytes. Here we report temporal regulation of the expression of this DNA sequence; furthermore, we show that this RNA is in the non-polyA+ fraction of total cellular RNA. These data suggest that coordinate regulation of this and other genes is important in promoting differentiation.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalFEBS Letters
Volume385
Issue number1-2
DOIs
StatePublished - Apr 29 1996

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Keywords

  • Adipocyte differentiation
  • RNA expression
  • Temporal regulation

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