The apolipoprotein є4 allele in Parkinson’s disease with and without dementia

K. Marder; G. Maestre; L. Cote; H. Mejia; B. Alfaro; A. Halim; M. Tang; B. Tycko; R. Mayeux

doi:10.1212/wnl.44.7.1330

The apolipoprotein є4 allele in Parkinson’s disease with and without dementia

K. Marder
, G. Maestre
, L. Cote
, H. Mejia
, B. Alfaro
, A. Halim
, M. Tang
, B. Tycko
, R. Mayeux

Center for Discovery and Innovation

Hackensack Meridian School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The є4 isoform of apolipoprotein E (Apo-E) may confer genetic susceptibility for familial and sporadic Alzheimer’s disease (AD). Because dementia in AD and Parkinson’s disease (PD) share many biologic and clinical features, we determined the Apo-E genotypes for 79 patients with PD, 22 of whom were demented, and for 44 age-matched healthy elderly controls from the same community. We hypothesized that if the dementia was similar to AD, there would be a higher allele frequency of apolipoprotein є4 (Apoє4) in demented PD patients compared with nondemented PD patients and controls. The є4 allele frequency for PD without dementia was 0.132, for PD with dementia, 0.068, and for controls, 0.102. There was no association between Apoє4 and dementia in the PD patients. We conclude that the biologic basis for dementia in PD may differ from that of AD.

Original language	English
Pages (from-to)	1330-1331
Number of pages	2
Journal	Neurology
Volume	44
Issue number	7
DOIs	https://doi.org/10.1212/wnl.44.7.1330
State	Published - Jul 1994

ASJC Scopus subject areas

Clinical Neurology

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10.1212/wnl.44.7.1330

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title = "The apolipoprotein є4 allele in Parkinson{\textquoteright}s disease with and without dementia",

abstract = "The є4 isoform of apolipoprotein E (Apo-E) may confer genetic susceptibility for familial and sporadic Alzheimer{\textquoteright}s disease (AD). Because dementia in AD and Parkinson{\textquoteright}s disease (PD) share many biologic and clinical features, we determined the Apo-E genotypes for 79 patients with PD, 22 of whom were demented, and for 44 age-matched healthy elderly controls from the same community. We hypothesized that if the dementia was similar to AD, there would be a higher allele frequency of apolipoprotein є4 (Apoє4) in demented PD patients compared with nondemented PD patients and controls. The є4 allele frequency for PD without dementia was 0.132, for PD with dementia, 0.068, and for controls, 0.102. There was no association between Apoє4 and dementia in the PD patients. We conclude that the biologic basis for dementia in PD may differ from that of AD.",

author = "K. Marder and G. Maestre and L. Cote and H. Mejia and B. Alfaro and A. Halim and M. Tang and B. Tycko and R. Mayeux",

year = "1994",

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TY - JOUR

T1 - The apolipoprotein є4 allele in Parkinson’s disease with and without dementia

AU - Marder, K.

AU - Maestre, G.

AU - Cote, L.

AU - Mejia, H.

AU - Alfaro, B.

AU - Halim, A.

AU - Tang, M.

AU - Tycko, B.

AU - Mayeux, R.

PY - 1994/7

Y1 - 1994/7

N2 - The є4 isoform of apolipoprotein E (Apo-E) may confer genetic susceptibility for familial and sporadic Alzheimer’s disease (AD). Because dementia in AD and Parkinson’s disease (PD) share many biologic and clinical features, we determined the Apo-E genotypes for 79 patients with PD, 22 of whom were demented, and for 44 age-matched healthy elderly controls from the same community. We hypothesized that if the dementia was similar to AD, there would be a higher allele frequency of apolipoprotein є4 (Apoє4) in demented PD patients compared with nondemented PD patients and controls. The є4 allele frequency for PD without dementia was 0.132, for PD with dementia, 0.068, and for controls, 0.102. There was no association between Apoє4 and dementia in the PD patients. We conclude that the biologic basis for dementia in PD may differ from that of AD.

AB - The є4 isoform of apolipoprotein E (Apo-E) may confer genetic susceptibility for familial and sporadic Alzheimer’s disease (AD). Because dementia in AD and Parkinson’s disease (PD) share many biologic and clinical features, we determined the Apo-E genotypes for 79 patients with PD, 22 of whom were demented, and for 44 age-matched healthy elderly controls from the same community. We hypothesized that if the dementia was similar to AD, there would be a higher allele frequency of apolipoprotein є4 (Apoє4) in demented PD patients compared with nondemented PD patients and controls. The є4 allele frequency for PD without dementia was 0.132, for PD with dementia, 0.068, and for controls, 0.102. There was no association between Apoє4 and dementia in the PD patients. We conclude that the biologic basis for dementia in PD may differ from that of AD.

UR - https://www.scopus.com/pages/publications/0028168115

U2 - 10.1212/wnl.44.7.1330

DO - 10.1212/wnl.44.7.1330

M3 - Article

C2 - 8035940

SN - 0028-3878

VL - 44

SP - 1330

EP - 1331

JO - Neurology

JF - Neurology

IS - 7

ER -

The apolipoprotein є4 allele in Parkinson’s disease with and without dementia

Abstract

ASJC Scopus subject areas

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