Demineralised bone in a viscous hyaluronan carrier was processed at sterilising and sub-sterilising doses of gamma radiation (10.2, 17.2 and 29.5 kGy). The pH, viscosity and osteoinductivity were measured. Osteoinductivity (OI) measured by implantation in an athymic (nude) mouse demonstrated significant loss at a dose of 17.2 kGy; OI scores declined 53% (p = 0.024). Viscosity also declined with increasing radiation dose. pH was unaffected.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)