The Effect of Cold Gamma Radiation Sterilisation on the Properties of Demineralised Bone Matrix

Arthur A. Gertzman; Moon Hae Sunwoo; Denise Raushi; Michael Dunn

doi:https://doi.org/10.1533/9781845690779.3.151

The Effect of Cold Gamma Radiation Sterilisation on the Properties of Demineralised Bone Matrix

Arthur A. Gertzman, Moon Hae Sunwoo, Denise Raushi, Michael Dunn

Robert Wood Johnson Medical School (RWJMS), Orthopedic Surgery

Rutgers, The State University

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Demineralised bone in a viscous hyaluronan carrier was processed at sterilising and sub-sterilising doses of gamma radiation (10.2, 17.2 and 29.5 kGy). The pH, viscosity and osteoinductivity were measured. Osteoinductivity (OI) measured by implantation in an athymic (nude) mouse demonstrated significant loss at a dose of 17.2 kGy; OI scores declined 53% (p = 0.024). Viscosity also declined with increasing radiation dose. pH was unaffected.

Original language	American English
Title of host publication	Sterilisation of Tissues Using Ionising Radiations
Publisher	Elsevier Inc.
Pages	151-156
Number of pages	6
ISBN (Print)	1855738384, 9781855738386
DOIs	https://doi.org/10.1533/9781845690779.3.151
State	Published - May 6 2005

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Demineralised bone in a viscous hyaluronan carrier was processed at sterilising and sub-sterilising doses of gamma radiation (10.2, 17.2 and 29.5 kGy). The pH, viscosity and osteoinductivity were measured. Osteoinductivity (OI) measured by implantation in an athymic (nude) mouse demonstrated significant loss at a dose of 17.2 kGy; OI scores declined 53% (p = 0.024). Viscosity also declined with increasing radiation dose. pH was unaffected.",

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AU - Raushi, Denise

AU - Dunn, Michael

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AB - Demineralised bone in a viscous hyaluronan carrier was processed at sterilising and sub-sterilising doses of gamma radiation (10.2, 17.2 and 29.5 kGy). The pH, viscosity and osteoinductivity were measured. Osteoinductivity (OI) measured by implantation in an athymic (nude) mouse demonstrated significant loss at a dose of 17.2 kGy; OI scores declined 53% (p = 0.024). Viscosity also declined with increasing radiation dose. pH was unaffected.

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BT - Sterilisation of Tissues Using Ionising Radiations

PB - Elsevier Inc.

ER -

The Effect of Cold Gamma Radiation Sterilisation on the Properties of Demineralised Bone Matrix

Abstract

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