The effects of blood glucose control upon fracture healing in the BB Wistar rat with diabetes mellitus

Heather A. Beam, J. Russell Parsons, Sheldon S. Lin

Research output: Contribution to journalReview articlepeer-review

144 Scopus citations

Abstract

Several clinical series, analyzing fracture healing in patients with diabetes mellitus (DM), demonstrated significant incidence of delayed union, non-union, and pseudarthrosis. In this study, analysis was performed to evaluate the effects of blood glucose (BG) control on fracture healing in the DM BB Wistar rat, a rat strain that represents a close homology to Type I DM in man. Our study showed decreased cell proliferation at the fracture site as well as decreased mechanical stiffness and bony content in the poorly controlled DM rats. To determine the effect of BG control, DM rats were treated with insulin sufficient to maintain physiologic BG levels throughout the course of the study. Values of cellular proliferation, biomechanical properties and callus bone content in tightly controlled DM animals were not significantly different from values of non-DM control values. This study suggests that insulin treatment with resultant improved BG control will ameliorate the impaired early and late parameters of DM fracture healing.

Original languageEnglish (US)
Pages (from-to)1210-1216
Number of pages7
JournalJournal of Orthopaedic Research
Volume20
Issue number6
DOIs
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine

Keywords

  • BB Wistar rat
  • Diabetes mellitus
  • Fracture
  • Insulin

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