The electropharmacological effects of high dose resibufogenin on guinea pig cardiac muscle

J. Y. Li, L. Xie

Research output: Contribution to journalArticlepeer-review

Abstract

Electropharmacological effects of resibufogenin (RBG) on guinea pig papillary muscle were studied by means of conventional glass microelectrode technique. The results were as follows: After being treated with RBG, the resting potential (RP), action potential amplitude (APA), action potential duration (APD) and V(max) decreased, delayed afterdepolarization (DAD) and triggered arrhythmias were induced. The amplitude and coupling interval of DADs depended on the basic cycle length (BCL) of the stimulation. The effects of RBG on the membrane potential of papillary muscle were concentration-dependent.

Original languageEnglish (US)
Pages (from-to)110-113
Number of pages4
JournalChinese Pharmacological Bulletin
Volume10
Issue number2
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

Keywords

  • guinea pig papillary muscle
  • microelectrode
  • resibufogenin
  • triggered activity

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