The gene for the helix-loop-helix protein, Id, is specifically expressed in neural precursors

Melinda Duncan, Emanuel M. DiCicco-Bloom, Xin Xiang, Robert Benezra, Kiran Chada

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

While mammalian neurogenesis has been characterized extensively, the molecules involved in regulating neural cell determination and differentiation remain ill-defined. There is accruing evidence that various members of the basic helix-loop-helix (bHLH) protein family critically regulate these biological processes in a number of tissues. Id, a negative regulator of bHLH proteins, was found to exhibit peak gene expression during mouse embryogenesis with a striking pattern in the central nervous system. Id transcripts were specifically localized to undifferentiated neural precursors of the ventricular zone and were not present in their differentiated derivatives. In addition, in the peripheral nervous system, dorsal root ganglia sensory precursors, known to be undifferentiated while dividing, also expressed Id mRNA. However, in the sympathetic nervous system and adrenal medulla, where differentiation and division occur simultaneously in precursors, Id was not expressed. Since Id transcript abundance inversely correlated with differentiation, this protein, similar to its Drosophila homolog, extramacrochaetae, may play a negative regulatory role in neural differentiation.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalDevelopmental biology
Volume154
Issue number1
DOIs
StatePublished - Nov 1992

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology
  • Developmental Biology

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