The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing

Jean Pierre Etchegaray, Lei Zhong, Catherine Li, Telmo Henriques, Eileen Ablondi, Tomoyoshi Nakadai, Capucine Van Rechem, Christina Ferrer, Kenneth N. Ross, Jee Eun Choi, Ann Samarakkody, Fei Ji, Andrew Chang, Ruslan I. Sadreyev, Sridhar Ramaswamy, Sergei Nechaev, Johnathan R. Whetstine, Robert G. Roeder, Karen Adelman, Alon GorenRaul Mostoslavsky

Research output: Contribution to journalArticle

Abstract

Historically, histone deacetylases have been described as inhibitors of transcription initiation by compacting chromatin at the transcriptional starting site. Etchegaray et al. identified the histone deacetylase SIRT6 as a critical modulator of transcriptional pausing and elongation, acting downstream of recruitment of Pol II.

Original languageEnglish (US)
Pages (from-to)683-699.e7
JournalMolecular cell
Volume75
Issue number4
DOIs
StatePublished - Aug 22 2019
Externally publishedYes

Fingerprint

Histone Deacetylases
Chromatin

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Keywords

  • BRD4
  • NELF
  • SIRT6
  • chromatin
  • epigenetics
  • histone deacetylation
  • transcription elongation
  • transcriptional pausing

Cite this

Etchegaray, J. P., Zhong, L., Li, C., Henriques, T., Ablondi, E., Nakadai, T., ... Mostoslavsky, R. (2019). The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. Molecular cell, 75(4), 683-699.e7. https://doi.org/10.1016/j.molcel.2019.06.034
Etchegaray, Jean Pierre ; Zhong, Lei ; Li, Catherine ; Henriques, Telmo ; Ablondi, Eileen ; Nakadai, Tomoyoshi ; Van Rechem, Capucine ; Ferrer, Christina ; Ross, Kenneth N. ; Choi, Jee Eun ; Samarakkody, Ann ; Ji, Fei ; Chang, Andrew ; Sadreyev, Ruslan I. ; Ramaswamy, Sridhar ; Nechaev, Sergei ; Whetstine, Johnathan R. ; Roeder, Robert G. ; Adelman, Karen ; Goren, Alon ; Mostoslavsky, Raul. / The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. In: Molecular cell. 2019 ; Vol. 75, No. 4. pp. 683-699.e7.
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Etchegaray, JP, Zhong, L, Li, C, Henriques, T, Ablondi, E, Nakadai, T, Van Rechem, C, Ferrer, C, Ross, KN, Choi, JE, Samarakkody, A, Ji, F, Chang, A, Sadreyev, RI, Ramaswamy, S, Nechaev, S, Whetstine, JR, Roeder, RG, Adelman, K, Goren, A & Mostoslavsky, R 2019, 'The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing', Molecular cell, vol. 75, no. 4, pp. 683-699.e7. https://doi.org/10.1016/j.molcel.2019.06.034

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. / Etchegaray, Jean Pierre; Zhong, Lei; Li, Catherine; Henriques, Telmo; Ablondi, Eileen; Nakadai, Tomoyoshi; Van Rechem, Capucine; Ferrer, Christina; Ross, Kenneth N.; Choi, Jee Eun; Samarakkody, Ann; Ji, Fei; Chang, Andrew; Sadreyev, Ruslan I.; Ramaswamy, Sridhar; Nechaev, Sergei; Whetstine, Johnathan R.; Roeder, Robert G.; Adelman, Karen; Goren, Alon; Mostoslavsky, Raul.

In: Molecular cell, Vol. 75, No. 4, 22.08.2019, p. 683-699.e7.

Research output: Contribution to journalArticle

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AU - Etchegaray, Jean Pierre

AU - Zhong, Lei

AU - Li, Catherine

AU - Henriques, Telmo

AU - Ablondi, Eileen

AU - Nakadai, Tomoyoshi

AU - Van Rechem, Capucine

AU - Ferrer, Christina

AU - Ross, Kenneth N.

AU - Choi, Jee Eun

AU - Samarakkody, Ann

AU - Ji, Fei

AU - Chang, Andrew

AU - Sadreyev, Ruslan I.

AU - Ramaswamy, Sridhar

AU - Nechaev, Sergei

AU - Whetstine, Johnathan R.

AU - Roeder, Robert G.

AU - Adelman, Karen

AU - Goren, Alon

AU - Mostoslavsky, Raul

PY - 2019/8/22

Y1 - 2019/8/22

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KW - NELF

KW - SIRT6

KW - chromatin

KW - epigenetics

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KW - transcription elongation

KW - transcriptional pausing

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