The ineffectiveness of random donor platelet transfusion in splenectomized, alloimmunized recipients

D. E. Hogge, J. P. Dutcher, J. Aisner, C. A. Schiffer

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The effect of splenectomy on the response to random donor platelet transfusion in 15 multitransfused thrombocytopenic patients is presented. Eight patients responded poorly, with low corrected platelet count increments at 1 and 24 hours posttransfusion. These eight patients were clinically alloimmunized and had lymphocytotoxic antibody (LCTAb) in their sera. They responded well to closely HLA-matched transfusions. In contrast, seven splenectomized patients responded well to random donor platelets. Five of these patients had no LCTAb and no other evidence of immunization. Two patients who responded well to random donor platelets had 'weak' LCTAb, and one responded to platelets presplenectomy in the presence of this antibody. Splenectomy does not improve the response to random donor platelets in alloimmunized recipients.

Original languageEnglish (US)
Pages (from-to)253-256
Number of pages4
JournalBlood
Volume64
Issue number1
DOIs
StatePublished - 1984

All Science Journal Classification (ASJC) codes

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

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