The INSPIRE comparative cost study: 12-month health economic and clinical outcomes associated with hysterectomy, myomectomy, and treatment with the sonata system

Elizabeth Brooks; Linda Mihalov; Dipak Delvadia; Joseph Hudgens; Saifuddin Mama; Gretchen E. Makai; Matt W. Yuen; Carter A. Little; Robert L. Bauserman; April Zambelli-Weiner; David J. Levine

doi:10.2147/CEOR.S214755

The INSPIRE comparative cost study: 12-month health economic and clinical outcomes associated with hysterectomy, myomectomy, and treatment with the sonata system

Elizabeth Brooks
, Linda Mihalov
, Dipak Delvadia
, Joseph Hudgens
, Saifuddin Mama
, Gretchen E. Makai
, Matt W. Yuen
, Carter A. Little
, Robert L. Bauserman
, April Zambelli-Weiner
, David J. Levine

CMSRU Faculty Affairs

Rowan University

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: The INSPIRE study compared perioperative and 12-month health economic and clinical outcomes associated with hysterectomy, myomectomy, and sonography-guided transcervical fibroid ablation (TFA) using the Sonata® system. Patients and Methods: Cost and health care resource utilization (HCRU) data for TFA were obtained from a prospective, multicenter, single-arm clinical trial. Data for hysterectomy and myomectomy arms were derived from the Truven Health MarketScan commercial payer claims database. The Truven data was used to determine health economic outcomes and costs for the hysterectomy and myomectomy arms. For each arm, payer perspective costs were estimated from the available charge and HCRU data. Results: TFA with Sonata had significantly lower mean length of stay (LOS) of 5 hrs versus hysterectomy (73 hrs) or myomectomy (79 hrs; all p< 0.001). The average payer cost for TFA treatment, including the associated postoperative HCRU was $8,941. This was significantly lower compared to hysterectomy ($24,156) and myomectomy ($22,784; all p< 0.001). In the TFA arm, there were no device-or procedure-related costs associated with complications during the peri-or postoperative time frame. TFA subjects had significantly lower costs associated with complications, prescription medications, and radiology. Conclusion: Compared to hysterectomy and myomectomy, TFA treatment with the Sonata system was associated with significantly lower index procedure cost, complication cost, and LOS, contributing to a lower total payer cost through 12 months.

Original language	English (US)
Pages (from-to)	1-11
Number of pages	11
Journal	ClinicoEconomics and Outcomes Research
Volume	12
DOIs	https://doi.org/10.2147/CEOR.S214755
State	Published - 2020

ASJC Scopus subject areas

Economics, Econometrics and Finance (miscellaneous)
Health Policy

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10.2147/CEOR.S214755

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Brooks, E., Mihalov, L., Delvadia, D., Hudgens, J., Mama, S., Makai, G. E., Yuen, M. W., Little, C. A., Bauserman, R. L., Zambelli-Weiner, A., & Levine, D. J. (2020). The INSPIRE comparative cost study: 12-month health economic and clinical outcomes associated with hysterectomy, myomectomy, and treatment with the sonata system. ClinicoEconomics and Outcomes Research, 12, 1-11. https://doi.org/10.2147/CEOR.S214755

@article{b2b0d30bd5714b2687037480fb647d8d,

title = "The INSPIRE comparative cost study: 12-month health economic and clinical outcomes associated with hysterectomy, myomectomy, and treatment with the sonata system",

abstract = "Purpose: The INSPIRE study compared perioperative and 12-month health economic and clinical outcomes associated with hysterectomy, myomectomy, and sonography-guided transcervical fibroid ablation (TFA) using the Sonata{\textregistered} system. Patients and Methods: Cost and health care resource utilization (HCRU) data for TFA were obtained from a prospective, multicenter, single-arm clinical trial. Data for hysterectomy and myomectomy arms were derived from the Truven Health MarketScan commercial payer claims database. The Truven data was used to determine health economic outcomes and costs for the hysterectomy and myomectomy arms. For each arm, payer perspective costs were estimated from the available charge and HCRU data. Results: TFA with Sonata had significantly lower mean length of stay (LOS) of 5 hrs versus hysterectomy (73 hrs) or myomectomy (79 hrs; all p< 0.001). The average payer cost for TFA treatment, including the associated postoperative HCRU was \$8,941. This was significantly lower compared to hysterectomy (\$24,156) and myomectomy (\$22,784; all p< 0.001). In the TFA arm, there were no device-or procedure-related costs associated with complications during the peri-or postoperative time frame. TFA subjects had significantly lower costs associated with complications, prescription medications, and radiology. Conclusion: Compared to hysterectomy and myomectomy, TFA treatment with the Sonata system was associated with significantly lower index procedure cost, complication cost, and LOS, contributing to a lower total payer cost through 12 months.",

author = "Elizabeth Brooks and Linda Mihalov and Dipak Delvadia and Joseph Hudgens and Saifuddin Mama and Makai, \{Gretchen E.\} and Yuen, \{Matt W.\} and Little, \{Carter A.\} and Bauserman, \{Robert L.\} and April Zambelli-Weiner and Levine, \{David J.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Brooks et al.",

year = "2020",

doi = "10.2147/CEOR.S214755",

language = "English (US)",

volume = "12",

pages = "1--11",

journal = "ClinicoEconomics and Outcomes Research",

issn = "1178-6981",

publisher = "Dove Medical Press Ltd",

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Brooks, E, Mihalov, L, Delvadia, D, Hudgens, J, Mama, S, Makai, GE, Yuen, MW, Little, CA, Bauserman, RL, Zambelli-Weiner, A & Levine, DJ 2020, 'The INSPIRE comparative cost study: 12-month health economic and clinical outcomes associated with hysterectomy, myomectomy, and treatment with the sonata system', ClinicoEconomics and Outcomes Research, vol. 12, pp. 1-11. https://doi.org/10.2147/CEOR.S214755

TY - JOUR

T1 - The INSPIRE comparative cost study

T2 - 12-month health economic and clinical outcomes associated with hysterectomy, myomectomy, and treatment with the sonata system

AU - Brooks, Elizabeth

AU - Mihalov, Linda

AU - Delvadia, Dipak

AU - Hudgens, Joseph

AU - Mama, Saifuddin

AU - Makai, Gretchen E.

AU - Yuen, Matt W.

AU - Little, Carter A.

AU - Bauserman, Robert L.

AU - Zambelli-Weiner, April

AU - Levine, David J.

PY - 2020

Y1 - 2020

N2 - Purpose: The INSPIRE study compared perioperative and 12-month health economic and clinical outcomes associated with hysterectomy, myomectomy, and sonography-guided transcervical fibroid ablation (TFA) using the Sonata® system. Patients and Methods: Cost and health care resource utilization (HCRU) data for TFA were obtained from a prospective, multicenter, single-arm clinical trial. Data for hysterectomy and myomectomy arms were derived from the Truven Health MarketScan commercial payer claims database. The Truven data was used to determine health economic outcomes and costs for the hysterectomy and myomectomy arms. For each arm, payer perspective costs were estimated from the available charge and HCRU data. Results: TFA with Sonata had significantly lower mean length of stay (LOS) of 5 hrs versus hysterectomy (73 hrs) or myomectomy (79 hrs; all p< 0.001). The average payer cost for TFA treatment, including the associated postoperative HCRU was $8,941. This was significantly lower compared to hysterectomy ($24,156) and myomectomy ($22,784; all p< 0.001). In the TFA arm, there were no device-or procedure-related costs associated with complications during the peri-or postoperative time frame. TFA subjects had significantly lower costs associated with complications, prescription medications, and radiology. Conclusion: Compared to hysterectomy and myomectomy, TFA treatment with the Sonata system was associated with significantly lower index procedure cost, complication cost, and LOS, contributing to a lower total payer cost through 12 months.

AB - Purpose: The INSPIRE study compared perioperative and 12-month health economic and clinical outcomes associated with hysterectomy, myomectomy, and sonography-guided transcervical fibroid ablation (TFA) using the Sonata® system. Patients and Methods: Cost and health care resource utilization (HCRU) data for TFA were obtained from a prospective, multicenter, single-arm clinical trial. Data for hysterectomy and myomectomy arms were derived from the Truven Health MarketScan commercial payer claims database. The Truven data was used to determine health economic outcomes and costs for the hysterectomy and myomectomy arms. For each arm, payer perspective costs were estimated from the available charge and HCRU data. Results: TFA with Sonata had significantly lower mean length of stay (LOS) of 5 hrs versus hysterectomy (73 hrs) or myomectomy (79 hrs; all p< 0.001). The average payer cost for TFA treatment, including the associated postoperative HCRU was $8,941. This was significantly lower compared to hysterectomy ($24,156) and myomectomy ($22,784; all p< 0.001). In the TFA arm, there were no device-or procedure-related costs associated with complications during the peri-or postoperative time frame. TFA subjects had significantly lower costs associated with complications, prescription medications, and radiology. Conclusion: Compared to hysterectomy and myomectomy, TFA treatment with the Sonata system was associated with significantly lower index procedure cost, complication cost, and LOS, contributing to a lower total payer cost through 12 months.

UR - https://www.scopus.com/pages/publications/85078243026

UR - https://www.scopus.com/pages/publications/85078243026#tab=citedBy

U2 - 10.2147/CEOR.S214755

DO - 10.2147/CEOR.S214755

M3 - Article

SN - 1178-6981

VL - 12

SP - 1

EP - 11

JO - ClinicoEconomics and Outcomes Research

JF - ClinicoEconomics and Outcomes Research

ER -

The INSPIRE comparative cost study: 12-month health economic and clinical outcomes associated with hysterectomy, myomectomy, and treatment with the sonata system

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