The nuclear receptor superfamily of steroid hormones and vitamin D gene regulation

An update

Ronald N. Margolis, Sylvia Christakos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

39 Citations (Scopus)

Abstract

Nuclear receptors bind to chromatin and seed formation of complexes comprising coregulators at the hormone response element. Nuclear receptors and coregulators can mediate chromatin remodeling, epigenetic modification, and ultimately gene expression. Chromatin immunoprecipitation has shown that nuclear receptors bind to chromatin throughout the genome, often at locations distant from the transcription start site. New findings related to the regulation of key vitamin D target genes in intestine and bone as well as nonclassical actions of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], including effects on breast cancer cells and on the immune system, are discussed. These studies will form the basis for future studies examining global networks regulated by the vitamin D receptor. It is becoming increasingly recognized that the actions of 1,25(OH)2D3, similar to those of other steroids, is complex, involving regulation of gene activity at a range of locations.

Original languageEnglish (US)
Title of host publicationSkeletal Biology and Medicine
PublisherBlackwell Publishing Inc.
Pages208-214
Number of pages7
ISBN (Print)9781573317856
DOIs
StatePublished - Jan 1 2010

Publication series

NameAnnals of the New York Academy of Sciences
Volume1192

Fingerprint

Steroid hormones
Cytoplasmic and Nuclear Receptors
Gene expression
Vitamin D
Chromatin
Steroids
Hormones
Genes
Calcitriol Receptors
Chromatin Assembly and Disassembly
Calcitriol
Chromatin Immunoprecipitation
Transcription Initiation Site
Response Elements
Epigenomics
Intestines
Immune system
Immune System
Seeds
Genome

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Neuroscience(all)
  • History and Philosophy of Science

Cite this

Margolis, R. N., & Christakos, S. (2010). The nuclear receptor superfamily of steroid hormones and vitamin D gene regulation: An update. In Skeletal Biology and Medicine (pp. 208-214). (Annals of the New York Academy of Sciences; Vol. 1192). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.05227.x
Margolis, Ronald N. ; Christakos, Sylvia. / The nuclear receptor superfamily of steroid hormones and vitamin D gene regulation : An update. Skeletal Biology and Medicine. Blackwell Publishing Inc., 2010. pp. 208-214 (Annals of the New York Academy of Sciences).
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Margolis, RN & Christakos, S 2010, The nuclear receptor superfamily of steroid hormones and vitamin D gene regulation: An update. in Skeletal Biology and Medicine. Annals of the New York Academy of Sciences, vol. 1192, Blackwell Publishing Inc., pp. 208-214. https://doi.org/10.1111/j.1749-6632.2009.05227.x

The nuclear receptor superfamily of steroid hormones and vitamin D gene regulation : An update. / Margolis, Ronald N.; Christakos, Sylvia.

Skeletal Biology and Medicine. Blackwell Publishing Inc., 2010. p. 208-214 (Annals of the New York Academy of Sciences; Vol. 1192).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Margolis RN, Christakos S. The nuclear receptor superfamily of steroid hormones and vitamin D gene regulation: An update. In Skeletal Biology and Medicine. Blackwell Publishing Inc. 2010. p. 208-214. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2009.05227.x