The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons

Brian P. Daniels, Sigal B. Kofman, Julian R. Smith, Geoffrey T. Norris, Annelise G. Snyder, Joseph P. Kolb, Xia Gao, Jason W. Locasale, Jennifer Martinez, Michael Gale, Yueh Ming Loo, Andrew Oberst

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Daniels et al. find that molecules traditionally associated with necroptotic cell death engage a death-independent transcriptional program in neurons during Zika virus infection. This transcriptional program includes the enzyme IRG1, whose product, itaconate, reprograms neuronal metabolism in a manner that restricts Zika virus replication.

Original languageEnglish (US)
Pages (from-to)64-76.e4
JournalImmunity
Volume50
Issue number1
DOIs
StatePublished - Jan 15 2019
Externally publishedYes

Fingerprint

Virus Replication
Antiviral Agents
Cell Death
Phosphotransferases
Nucleotides
Neurons
Enzymes
Zika Virus Infection
Zika Virus
itaconic acid

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology

Cite this

Daniels, Brian P. ; Kofman, Sigal B. ; Smith, Julian R. ; Norris, Geoffrey T. ; Snyder, Annelise G. ; Kolb, Joseph P. ; Gao, Xia ; Locasale, Jason W. ; Martinez, Jennifer ; Gale, Michael ; Loo, Yueh Ming ; Oberst, Andrew. / The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons. In: Immunity. 2019 ; Vol. 50, No. 1. pp. 64-76.e4.
@article{64dd7c1b100248aeb36aa6f178160920,
title = "The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons",
abstract = "Daniels et al. find that molecules traditionally associated with necroptotic cell death engage a death-independent transcriptional program in neurons during Zika virus infection. This transcriptional program includes the enzyme IRG1, whose product, itaconate, reprograms neuronal metabolism in a manner that restricts Zika virus replication.",
author = "Daniels, {Brian P.} and Kofman, {Sigal B.} and Smith, {Julian R.} and Norris, {Geoffrey T.} and Snyder, {Annelise G.} and Kolb, {Joseph P.} and Xia Gao and Locasale, {Jason W.} and Jennifer Martinez and Michael Gale and Loo, {Yueh Ming} and Andrew Oberst",
year = "2019",
month = "1",
day = "15",
doi = "https://doi.org/10.1016/j.immuni.2018.11.017",
language = "English (US)",
volume = "50",
pages = "64--76.e4",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "1",

}

Daniels, BP, Kofman, SB, Smith, JR, Norris, GT, Snyder, AG, Kolb, JP, Gao, X, Locasale, JW, Martinez, J, Gale, M, Loo, YM & Oberst, A 2019, 'The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons', Immunity, vol. 50, no. 1, pp. 64-76.e4. https://doi.org/10.1016/j.immuni.2018.11.017

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons. / Daniels, Brian P.; Kofman, Sigal B.; Smith, Julian R.; Norris, Geoffrey T.; Snyder, Annelise G.; Kolb, Joseph P.; Gao, Xia; Locasale, Jason W.; Martinez, Jennifer; Gale, Michael; Loo, Yueh Ming; Oberst, Andrew.

In: Immunity, Vol. 50, No. 1, 15.01.2019, p. 64-76.e4.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons

AU - Daniels, Brian P.

AU - Kofman, Sigal B.

AU - Smith, Julian R.

AU - Norris, Geoffrey T.

AU - Snyder, Annelise G.

AU - Kolb, Joseph P.

AU - Gao, Xia

AU - Locasale, Jason W.

AU - Martinez, Jennifer

AU - Gale, Michael

AU - Loo, Yueh Ming

AU - Oberst, Andrew

PY - 2019/1/15

Y1 - 2019/1/15

N2 - Daniels et al. find that molecules traditionally associated with necroptotic cell death engage a death-independent transcriptional program in neurons during Zika virus infection. This transcriptional program includes the enzyme IRG1, whose product, itaconate, reprograms neuronal metabolism in a manner that restricts Zika virus replication.

AB - Daniels et al. find that molecules traditionally associated with necroptotic cell death engage a death-independent transcriptional program in neurons during Zika virus infection. This transcriptional program includes the enzyme IRG1, whose product, itaconate, reprograms neuronal metabolism in a manner that restricts Zika virus replication.

UR - http://www.scopus.com/inward/record.url?scp=85059793906&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059793906&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.immuni.2018.11.017

DO - https://doi.org/10.1016/j.immuni.2018.11.017

M3 - Article

C2 - 30635240

VL - 50

SP - 64-76.e4

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 1

ER -