The Pathology of Acute Liver Failure

Billie Fyfe, Francisco Zaldana, Chen Liu

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Varied injuries may manifest clinically as acute liver failure. The pathologic features include variable amounts of necrosis and regeneration. This article reviews pathologic classification of patterns of necrosis and associated inflammatory and regenerative responses in specimens from patients with acute liver failure. Detailed pathologic examination of these specimens with clinical pathologic correlation can give the multidisciplinary team vital information regarding etiology and timing as well as extent of injury, and regenerative response. Pathologists are a vital component of the health care team for patients with acute liver failure.

Original languageEnglish (US)
Pages (from-to)257-268
Number of pages12
JournalClinics in Liver Disease
Issue number2
StatePublished - May 2018

All Science Journal Classification (ASJC) codes

  • Hepatology


  • Acetaminophen
  • Acute liver failure pathology
  • Autoimmune hepatitis
  • Hepatotropic viral hepatitis
  • Massive hepatic necrosis
  • Submassive hepatic necrosis
  • Zonal necrosis

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