Abstract
Hyperoxia-induced acute lung injury (HALI) is characterized by an influx of inflammatory cells, increased pulmonary permeability, endothelial and epithelial cell death. In a murine model and in vitro, we found Angiopoietin 2 to be a critical mediator of lung oxidant injury, inflammation, edema, and regulator of necrotic cell death pathways. The clinical significance of our findings was highlighted by the detection of increased Angiopoietin 2 levels in patients with ALI.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1049-1052 |
| Number of pages | 4 |
| Journal | Cell Cycle |
| Volume | 6 |
| Issue number | 9 |
| DOIs | |
| State | Published - May 1 2007 |
| Externally published | Yes |
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology
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