The role of arterial baroreceptors in mediating the cardiovascular response to a cardiac glycoside in conscious dogs

R. J. McRitchie, Stephen Vatner

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

To determine the role of the arterial baroreceptor reflex in mediating the cardiovascular response to a cardiac glycoside, the authors examined the effects of ouabain (G strophanthin), 17.5 μg/kg, iv, on direct and continuous measurements of left ventricular diameters, pressures, velocity of shortening, (dP/dt)/P, arterial pressure, cardiac output, and total peripheral resistance. These studies were conducted on healthy conscious dogs before and after total arterial baroreceptor denervation (TABD). Maximal pressor effects were observed in the first 3-5 minutes; mean arterial pressure increased by 11 ± 1 mm Hg in normal dogs compared to 33 ± 4 mm Hg in denervated dogs. In intact dogs at this time heart rate decreased by 18 ± 2 beats/min and cardiac output fell by 18 ± 3%; these values gradually returned toward control over 15-30 minutes. When heart rate was kept constant, cardiac output did not fall after injection of ouabain. In contrast, heart rate and cardiac output did not change significantly after ouabain in dogs with TABD. The maximal effects on the contractile state of the heart occurred between 15-30 minutes and were similar in both groups. Arterial baroreceptor reflexes appear to be responsible for the reduction in heart rate and cardiac output caused by administration of ouabain to the intact dog. They exert an important buffering action on the vasopressor effect but a less important action on the inotropic response.

Original languageEnglish (US)
Pages (from-to)321-326
Number of pages6
JournalCirculation research
Volume38
Issue number4
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

Fingerprint

Cardiac Glycosides
Pressoreceptors
Ouabain
Cardiac Output
Dogs
Heart Rate
Baroreflex
Denervation
Arterial Pressure
Ventricular Pressure
Vascular Resistance
Injections

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

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abstract = "To determine the role of the arterial baroreceptor reflex in mediating the cardiovascular response to a cardiac glycoside, the authors examined the effects of ouabain (G strophanthin), 17.5 μg/kg, iv, on direct and continuous measurements of left ventricular diameters, pressures, velocity of shortening, (dP/dt)/P, arterial pressure, cardiac output, and total peripheral resistance. These studies were conducted on healthy conscious dogs before and after total arterial baroreceptor denervation (TABD). Maximal pressor effects were observed in the first 3-5 minutes; mean arterial pressure increased by 11 ± 1 mm Hg in normal dogs compared to 33 ± 4 mm Hg in denervated dogs. In intact dogs at this time heart rate decreased by 18 ± 2 beats/min and cardiac output fell by 18 ± 3{\%}; these values gradually returned toward control over 15-30 minutes. When heart rate was kept constant, cardiac output did not fall after injection of ouabain. In contrast, heart rate and cardiac output did not change significantly after ouabain in dogs with TABD. The maximal effects on the contractile state of the heart occurred between 15-30 minutes and were similar in both groups. Arterial baroreceptor reflexes appear to be responsible for the reduction in heart rate and cardiac output caused by administration of ouabain to the intact dog. They exert an important buffering action on the vasopressor effect but a less important action on the inotropic response.",
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The role of arterial baroreceptors in mediating the cardiovascular response to a cardiac glycoside in conscious dogs. / McRitchie, R. J.; Vatner, Stephen.

In: Circulation research, Vol. 38, No. 4, 01.01.1976, p. 321-326.

Research output: Contribution to journalArticle

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