The Role of Chemotherapy in the Management of Sinonasal and Ventral Skull Base Malignancies

George A. Scangas, Jean Eloy, Derrick T. Lin

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

In most cases of advanced sinonasal and ventral skull base cancer, a multimodal treatment approach provides the best chance for improved outcomes. Depending on the tumor type and extent of disease, systemic chemotherapy has been shown to play an important role in neoadjuvant, concomitant, and adjuvant settings. The lack of randomized trials continues to limit its indications. Further high-quality studies are needed to understand ideal chemotherapeutic regimens and their role and sequential timing in sinonasal and ventral skull base cancer.

Original languageEnglish (US)
Pages (from-to)433-441
Number of pages9
JournalOtolaryngologic Clinics of North America
Volume50
Issue number2
DOIs
StatePublished - Apr 1 2017

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Skull Base
Drug Therapy
Combined Modality Therapy
Neoplasms

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Keywords

  • Chemotherapy
  • Multimodality therapy
  • Neoadjuvant chemotherapy
  • Sinonasal cancer
  • Sinonasal tumor
  • Systemic treatment

Cite this

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abstract = "In most cases of advanced sinonasal and ventral skull base cancer, a multimodal treatment approach provides the best chance for improved outcomes. Depending on the tumor type and extent of disease, systemic chemotherapy has been shown to play an important role in neoadjuvant, concomitant, and adjuvant settings. The lack of randomized trials continues to limit its indications. Further high-quality studies are needed to understand ideal chemotherapeutic regimens and their role and sequential timing in sinonasal and ventral skull base cancer.",
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The Role of Chemotherapy in the Management of Sinonasal and Ventral Skull Base Malignancies. / Scangas, George A.; Eloy, Jean; Lin, Derrick T.

In: Otolaryngologic Clinics of North America, Vol. 50, No. 2, 01.04.2017, p. 433-441.

Research output: Contribution to journalReview article

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AB - In most cases of advanced sinonasal and ventral skull base cancer, a multimodal treatment approach provides the best chance for improved outcomes. Depending on the tumor type and extent of disease, systemic chemotherapy has been shown to play an important role in neoadjuvant, concomitant, and adjuvant settings. The lack of randomized trials continues to limit its indications. Further high-quality studies are needed to understand ideal chemotherapeutic regimens and their role and sequential timing in sinonasal and ventral skull base cancer.

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