The role of leucine and its metabolites in protein and energy metabolism

Yehui Duan, Fengna Li, Yinghui Li, Yulong Tang, Xiangfeng Kong, Zemeng Feng, Tracy Anthony, Malcolm Watford, Yongqing Hou, Guoyao Wu, Yulong Yin

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Leucine (Leu) is a nutritionally essential branched-chain amino acid (BCAA) in animal nutrition. It is usually one of the most abundant amino acids in high-quality protein foods. Leu increases protein synthesis through activation of the mammalian target of rapamycin (mTOR) signaling pathway in skeletal muscle, adipose tissue and placental cells. Leu promotes energy metabolism (glucose uptake, mitochondrial biogenesis, and fatty acid oxidation) to provide energy for protein synthesis, while inhibiting protein degradation. Approximately 80 % of Leu is normally used for protein synthesis, while the remainder is converted to α-ketoisocaproate (α-KIC) and β-hydroxy-β-methylbutyrate (HMB) in skeletal muscle. Therefore, it has been hypothesized that some of the functions of Leu are modulated by its metabolites. Both α-KIC and HMB have recently received considerable attention as nutritional supplements used to increase protein synthesis, inhibit protein degradation, and regulate energy homeostasis in a variety of in vitro and in vivo models. Leu and its metabolites hold great promise to enhance the growth and health of animals (including humans, birds and fish).

Original languageEnglish (US)
Pages (from-to)41-51
Number of pages11
JournalAmino Acids
Volume48
Issue number1
DOIs
StatePublished - Jan 1 2016

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Metabolites
Leucine
Energy Metabolism
Proteins
Proteolysis
Skeletal Muscle
Muscle
Animals
Branched Chain Amino Acids
Food Quality
Essential Amino Acids
Degradation
Organelle Biogenesis
Sirolimus
Birds
Nutrition
Adipose Tissue
Fishes
Homeostasis
Fish

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Duan, Y., Li, F., Li, Y., Tang, Y., Kong, X., Feng, Z., ... Yin, Y. (2016). The role of leucine and its metabolites in protein and energy metabolism. Amino Acids, 48(1), 41-51. https://doi.org/10.1007/s00726-015-2067-1
Duan, Yehui ; Li, Fengna ; Li, Yinghui ; Tang, Yulong ; Kong, Xiangfeng ; Feng, Zemeng ; Anthony, Tracy ; Watford, Malcolm ; Hou, Yongqing ; Wu, Guoyao ; Yin, Yulong. / The role of leucine and its metabolites in protein and energy metabolism. In: Amino Acids. 2016 ; Vol. 48, No. 1. pp. 41-51.
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Duan, Y, Li, F, Li, Y, Tang, Y, Kong, X, Feng, Z, Anthony, T, Watford, M, Hou, Y, Wu, G & Yin, Y 2016, 'The role of leucine and its metabolites in protein and energy metabolism', Amino Acids, vol. 48, no. 1, pp. 41-51. https://doi.org/10.1007/s00726-015-2067-1

The role of leucine and its metabolites in protein and energy metabolism. / Duan, Yehui; Li, Fengna; Li, Yinghui; Tang, Yulong; Kong, Xiangfeng; Feng, Zemeng; Anthony, Tracy; Watford, Malcolm; Hou, Yongqing; Wu, Guoyao; Yin, Yulong.

In: Amino Acids, Vol. 48, No. 1, 01.01.2016, p. 41-51.

Research output: Contribution to journalArticle

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AU - Anthony, Tracy

AU - Watford, Malcolm

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AU - Wu, Guoyao

AU - Yin, Yulong

PY - 2016/1/1

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