The Transcription Factor GABP Is a Critical Regulator of B Lymphocyte Development

Hai Hui Xue; Julie Bollenbacher-Reilley; Zheng Wu; Rosanne Spolski; Xuefang Jing; Yi Chen Zhang; J. Philip McCoy; Warren J. Leonard

doi:10.1016/j.immuni.2007.03.010

The Transcription Factor GABP Is a Critical Regulator of B Lymphocyte Development

Hai Hui Xue
, Julie Bollenbacher-Reilley
, Zheng Wu
, Rosanne Spolski
, Xuefang Jing
, Yi Chen Zhang
, J. Philip McCoy
, Warren J. Leonard

Center for Discovery and Innovation

Hackensack Meridian School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

GA binding protein (GABP) is a ubiquitously expressed Ets-family transcription factor that critically regulates the expression of the interleukin-7 receptor α chain (IL-7Rα) in T cells, whereas it is dispensable for IL-7Rα expression in fetal liver B cells. Here we showed that deficiency of GABPα, the DNA-binding subunit of GABP, resulted in profoundly defective B cell development and a compromised humoral immune response, in addition to thymic developmental defects. Furthermore, the expression of Pax5 and Pax5 target genes such as Cd79a was greatly diminished in GABPα-deficient B cell progenitors, pro-B, and mature B cells. GABP could bind to the regulatory regions of Pax5 and Cd79a in vivo. Thus, GABP is a key regulator of B cell development, maturation, and function.

Original language	English
Pages (from-to)	421-431
Number of pages	11
Journal	Immunity
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2007.03.010
State	Published - Apr 27 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

Keywords

MOLIMMUNO

Access to Document

10.1016/j.immuni.2007.03.010

Cite this

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title = "The Transcription Factor GABP Is a Critical Regulator of B Lymphocyte Development",

abstract = "GA binding protein (GABP) is a ubiquitously expressed Ets-family transcription factor that critically regulates the expression of the interleukin-7 receptor α chain (IL-7Rα) in T cells, whereas it is dispensable for IL-7Rα expression in fetal liver B cells. Here we showed that deficiency of GABPα, the DNA-binding subunit of GABP, resulted in profoundly defective B cell development and a compromised humoral immune response, in addition to thymic developmental defects. Furthermore, the expression of Pax5 and Pax5 target genes such as Cd79a was greatly diminished in GABPα-deficient B cell progenitors, pro-B, and mature B cells. GABP could bind to the regulatory regions of Pax5 and Cd79a in vivo. Thus, GABP is a key regulator of B cell development, maturation, and function.",

keywords = "MOLIMMUNO",

author = "Xue, \{Hai Hui\} and Julie Bollenbacher-Reilley and Zheng Wu and Rosanne Spolski and Xuefang Jing and Zhang, \{Yi Chen\} and McCoy, \{J. Philip\} and Leonard, \{Warren J.\}",

year = "2007",

month = apr,

day = "27",

doi = "10.1016/j.immuni.2007.03.010",

language = "English",

volume = "26",

pages = "421--431",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

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TY - JOUR

T1 - The Transcription Factor GABP Is a Critical Regulator of B Lymphocyte Development

AU - Xue, Hai Hui

AU - Bollenbacher-Reilley, Julie

AU - Wu, Zheng

AU - Spolski, Rosanne

AU - Jing, Xuefang

AU - Zhang, Yi Chen

AU - McCoy, J. Philip

AU - Leonard, Warren J.

PY - 2007/4/27

Y1 - 2007/4/27

N2 - GA binding protein (GABP) is a ubiquitously expressed Ets-family transcription factor that critically regulates the expression of the interleukin-7 receptor α chain (IL-7Rα) in T cells, whereas it is dispensable for IL-7Rα expression in fetal liver B cells. Here we showed that deficiency of GABPα, the DNA-binding subunit of GABP, resulted in profoundly defective B cell development and a compromised humoral immune response, in addition to thymic developmental defects. Furthermore, the expression of Pax5 and Pax5 target genes such as Cd79a was greatly diminished in GABPα-deficient B cell progenitors, pro-B, and mature B cells. GABP could bind to the regulatory regions of Pax5 and Cd79a in vivo. Thus, GABP is a key regulator of B cell development, maturation, and function.

AB - GA binding protein (GABP) is a ubiquitously expressed Ets-family transcription factor that critically regulates the expression of the interleukin-7 receptor α chain (IL-7Rα) in T cells, whereas it is dispensable for IL-7Rα expression in fetal liver B cells. Here we showed that deficiency of GABPα, the DNA-binding subunit of GABP, resulted in profoundly defective B cell development and a compromised humoral immune response, in addition to thymic developmental defects. Furthermore, the expression of Pax5 and Pax5 target genes such as Cd79a was greatly diminished in GABPα-deficient B cell progenitors, pro-B, and mature B cells. GABP could bind to the regulatory regions of Pax5 and Cd79a in vivo. Thus, GABP is a key regulator of B cell development, maturation, and function.

KW - MOLIMMUNO

UR - https://www.scopus.com/pages/publications/34247107198

U2 - 10.1016/j.immuni.2007.03.010

DO - 10.1016/j.immuni.2007.03.010

M3 - Article

C2 - 17442597

SN - 1074-7613

VL - 26

SP - 421

EP - 431

JO - Immunity

JF - Immunity

IS - 4

ER -

The Transcription Factor GABP Is a Critical Regulator of B Lymphocyte Development

Abstract

UN SDGs

ASJC Scopus subject areas

Keywords

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