Thinking outside the classical chain reaction box of lipid oxidation: Evidence for alternate pathways and the importance of epoxides

Karen M. Schaich; Jia Xie; Brandon A. Bogusz

doi:10.1002/lite.201700025

Thinking outside the classical chain reaction box of lipid oxidation: Evidence for alternate pathways and the importance of epoxides

Karen M. Schaich, Jia Xie, Brandon A. Bogusz

School of Environmental and Biological Sciences, Food Science

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Lipid oxidation has always been viewed as a simple free radical chain reaction with straightforward sequence of radicals → hydroperoxides → products. The first paper in this series proposed that alternate reactions of lipid peroxyl and alkoxyl radicals compete with hydrogen abstraction to make the process much more complex. This article provides experimental evidence for formation of epoxides as major products and shows how monitoring a broad spectrum of products is critical for accurate assessment of the extent of lipid oxidation, elucidating reaction pathways, and anticipating potential toxicity.

Original language	American English
Pages (from-to)	91-96
Number of pages	6
Journal	Lipid Technology
Volume	29
Issue number	9-10
DOIs	https://doi.org/10.1002/lite.201700025
State	Published - Oct 2017

ASJC Scopus subject areas

Control and Systems Engineering
Food Science
General Biochemistry, Genetics and Molecular Biology

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10.1002/lite.201700025

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abstract = "Lipid oxidation has always been viewed as a simple free radical chain reaction with straightforward sequence of radicals → hydroperoxides → products. The first paper in this series proposed that alternate reactions of lipid peroxyl and alkoxyl radicals compete with hydrogen abstraction to make the process much more complex. This article provides experimental evidence for formation of epoxides as major products and shows how monitoring a broad spectrum of products is critical for accurate assessment of the extent of lipid oxidation, elucidating reaction pathways, and anticipating potential toxicity.",

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Thinking outside the classical chain reaction box of lipid oxidation: Evidence for alternate pathways and the importance of epoxides

Abstract

ASJC Scopus subject areas

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