Time course changes in IGFBP-1 after treadmill exercise and postexercise food intake in rats

Tracy Anthony, J. C. Anthony, M. S. Lewitt, S. M. Donovan, D. K. Layman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Prolonged exercise increases circulating insulin-like growth factor binding protein-1 (IGFBP-1) in humans and animals, but its physiological significance is unknown. This study examined 1) time-course changes in plasma IGFBP-1 and hepatic IGFBP-1 mRNA expression after exercise, 2) changes in IGFBP-1 in relation to plasma glucose, insulin, and IGF-1, and 3) the impact of feeding a postexercise meal on the IGFBP-1 response. Food-deprived male rats were vigorously run on a treadmill and compared with nonexercised controls at 15 min and 1, 4, 8, and 12 h after exercise. Circulating insulin concentrations in exercised rats were lower than in controls at 15 min and 1 h, whereas plasma glucose and IGF-I remained unaffected. Circulating and hepatic expression of IGFBP-1 was markedly increased above that of controls at 15 min, 1 h, and 12 h. In a separate experiment, one-half of the exercised animals received a nutritionally complete meal immediately after the experimental run. The meal elevated plasma insulin and glucose concentrations at 15 min and 1 h. Despite this change in nutritional status, serum IGFBP-1 concentrations and hepatic IGFBP-1 abundance remained elevated at 15 min and 1 h. These results demonstrate that the IGFBP-1 response to a single bout of treadmill exercise is short in duration and independent of insulin, glucose, and amino acid availability.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume280
Issue number4 43-4
StatePublished - Apr 1 2001
Externally publishedYes

Fingerprint

Insulin-Like Growth Factor Binding Protein 1
Exercise equipment
Rats
Eating
Insulin
Meals
Glucose
Plasmas
Insulin-Like Growth Factor I
Liver
Animals
Nutritional Status
Amino Acids
Availability
Food
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Physiology (medical)
  • Physiology
  • Endocrinology, Diabetes and Metabolism

Cite this

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abstract = "Prolonged exercise increases circulating insulin-like growth factor binding protein-1 (IGFBP-1) in humans and animals, but its physiological significance is unknown. This study examined 1) time-course changes in plasma IGFBP-1 and hepatic IGFBP-1 mRNA expression after exercise, 2) changes in IGFBP-1 in relation to plasma glucose, insulin, and IGF-1, and 3) the impact of feeding a postexercise meal on the IGFBP-1 response. Food-deprived male rats were vigorously run on a treadmill and compared with nonexercised controls at 15 min and 1, 4, 8, and 12 h after exercise. Circulating insulin concentrations in exercised rats were lower than in controls at 15 min and 1 h, whereas plasma glucose and IGF-I remained unaffected. Circulating and hepatic expression of IGFBP-1 was markedly increased above that of controls at 15 min, 1 h, and 12 h. In a separate experiment, one-half of the exercised animals received a nutritionally complete meal immediately after the experimental run. The meal elevated plasma insulin and glucose concentrations at 15 min and 1 h. Despite this change in nutritional status, serum IGFBP-1 concentrations and hepatic IGFBP-1 abundance remained elevated at 15 min and 1 h. These results demonstrate that the IGFBP-1 response to a single bout of treadmill exercise is short in duration and independent of insulin, glucose, and amino acid availability.",
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Time course changes in IGFBP-1 after treadmill exercise and postexercise food intake in rats. / Anthony, Tracy; Anthony, J. C.; Lewitt, M. S.; Donovan, S. M.; Layman, D. K.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 280, No. 4 43-4, 01.04.2001.

Research output: Contribution to journalArticle

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