Tissue-Specific and Developmentally Regulated Transcription of the Insulin-Like Growth Factor 2 Gene

Alane Gray, Albert W. Tam, Thomas J. Dull, Joel Hayflick, John Pintar, Webster K. Cavenee, Alex Koufos, Axel Ullrich

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

Transcription of the rat and human IGF-2 gene loci is unusually complex. The pattern of expression of these genes varies both between tissues and within a given tissue during different stages of development. Alternative splicing or possibly transcriptional initiation events generate variant IGF-2 mRNAs that contain different 5′-untranslated leader sequences. These leader exon sequences are shared with non-IGF-2 mRNAs. Certain noncoding IGF-2 gene sequence elements are transcribed extensively and are found in multiple copies elsewhere in the human genome. Furthermore, IGF-2 mRNA levels are particularly high in a variety of human malignancies.

Original languageEnglish (US)
Pages (from-to)283-295
Number of pages13
JournalDNA
Volume6
Issue number4
DOIs
StatePublished - Aug 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Molecular Biology
  • Biochemistry

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