Tissue-specific repression of starvation and stress responses of the Neurospora crassa con-10 gene is mediated by RCO1

Kwangwon Lee, Daniel J. Ebbole

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The Neurospora crassa con-10 gene is weakly expressed in mycelia but is induced approximately 1000-fold during macroconidiation. Studies of the promoter elements and trans-acting factors that regulate con-10 expression are needed to gain a detailed understanding of developmental regulation. The rco-1 mutant displays a 10-fold elevated basal level of expression of con-10. In contrast to the wild type, con-10 expression in mycelia of the rco-1 mutant was rapidly induced to high levels by starvation for carbon or nitrogen and by heat shock. Although con-10 is developmentally induced late in conidiation, con-10 was inducible by heat shock shortly after exposure of the wild-type mycelium to air. These findings support the view that RCO1 is a cell type-specific repressor of con-10. We propose that inactivation of RCO1 allows developing conidiophores to adjust the timing of con-10 induction in response to stress.

Original languageEnglish (US)
Pages (from-to)269-278
Number of pages10
JournalFungal Genetics and Biology
Volume23
Issue number3
DOIs
StatePublished - Apr 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Microbiology

Keywords

  • Circadian clock-controlled gene
  • Fungal development
  • Saccharomyces cerevisiae
  • Sporulation
  • Stress response
  • TUP1

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