Tonic and phasic pyloric activity in response to CCK-octapeptide

Frank K. Friedenberg; Joshua DeSipio; Annapurna Korimilli; Matthew Bohning; Eva Sum; Henry P. Parkman; Joel E. Richter; Robert S. Fisher

doi:10.1007/s10620-008-0214-1

Tonic and phasic pyloric activity in response to CCK-octapeptide

Frank K. Friedenberg
, Joshua DeSipio
, Annapurna Korimilli
, Matthew Bohning
, Eva Sum
, Henry P. Parkman
, Joel E. Richter
, Robert S. Fisher

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The purpose of this study was to determine whether a high-resolution solid-state catheter system could detect regional pressure changes within the antrum and pylorus in response to CCK-octapeptide. Methods: Subjects received a 30 min infusion of CCK-octapeptide at either 0.02 or 0.06 μg kg^-1 h^-1. Results: Five males and two females were studied. Mean antral pressure during phase I MMC increased from 5.3 ± 2.1 to 9.9 ± 2.4 mmHg (P = 0.028) after infusion. At the pylorus, only the 0.06 μg kg^-1 h^-1 dose increased tonic pressure (8.8 ± 1.4 to 17.6 ± 2.0 mmHg; P = 0.01) as compared with the 0.02 μg kg^-1 h^-1 dose (4.7 ± 0.7 to 7.3 ± 0.4 mmHg; P = NS). The peak pressure of pyloric phasic pressure waves was 153 ± 28.4 mmHg and their frequency was 4.9 ± 1.1 contractions min^-1. Conclusions: CCK-octapeptide elicits both tonic and phasic activity of the pyloric sphincter. The contractile response to a dose of 0.06 μg kg^-1 h^-1 is greater than the response to 0.02 μg kg^-1 h^-1.

Original language	American English
Pages (from-to)	905-911
Number of pages	7
Journal	Digestive diseases and sciences
Volume	53
Issue number	4
DOIs	https://doi.org/10.1007/s10620-008-0214-1
State	Published - Apr 2008
Externally published	Yes

ASJC Scopus subject areas

Physiology
Gastroenterology

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10.1007/s10620-008-0214-1

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title = "Tonic and phasic pyloric activity in response to CCK-octapeptide",

abstract = "Background: The purpose of this study was to determine whether a high-resolution solid-state catheter system could detect regional pressure changes within the antrum and pylorus in response to CCK-octapeptide. Methods: Subjects received a 30 min infusion of CCK-octapeptide at either 0.02 or 0.06 μg kg-1 h-1. Results: Five males and two females were studied. Mean antral pressure during phase I MMC increased from 5.3 ± 2.1 to 9.9 ± 2.4 mmHg (P = 0.028) after infusion. At the pylorus, only the 0.06 μg kg-1 h-1 dose increased tonic pressure (8.8 ± 1.4 to 17.6 ± 2.0 mmHg; P = 0.01) as compared with the 0.02 μg kg-1 h-1 dose (4.7 ± 0.7 to 7.3 ± 0.4 mmHg; P = NS). The peak pressure of pyloric phasic pressure waves was 153 ± 28.4 mmHg and their frequency was 4.9 ± 1.1 contractions min-1. Conclusions: CCK-octapeptide elicits both tonic and phasic activity of the pyloric sphincter. The contractile response to a dose of 0.06 μg kg-1 h-1 is greater than the response to 0.02 μg kg-1 h-1.",

author = "Friedenberg, \{Frank K.\} and Joshua DeSipio and Annapurna Korimilli and Matthew Bohning and Eva Sum and Parkman, \{Henry P.\} and Richter, \{Joel E.\} and Fisher, \{Robert S.\}",

year = "2008",

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doi = "10.1007/s10620-008-0214-1",

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T1 - Tonic and phasic pyloric activity in response to CCK-octapeptide

AU - Friedenberg, Frank K.

AU - DeSipio, Joshua

AU - Korimilli, Annapurna

AU - Bohning, Matthew

AU - Sum, Eva

AU - Parkman, Henry P.

AU - Richter, Joel E.

AU - Fisher, Robert S.

PY - 2008/4

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N2 - Background: The purpose of this study was to determine whether a high-resolution solid-state catheter system could detect regional pressure changes within the antrum and pylorus in response to CCK-octapeptide. Methods: Subjects received a 30 min infusion of CCK-octapeptide at either 0.02 or 0.06 μg kg-1 h-1. Results: Five males and two females were studied. Mean antral pressure during phase I MMC increased from 5.3 ± 2.1 to 9.9 ± 2.4 mmHg (P = 0.028) after infusion. At the pylorus, only the 0.06 μg kg-1 h-1 dose increased tonic pressure (8.8 ± 1.4 to 17.6 ± 2.0 mmHg; P = 0.01) as compared with the 0.02 μg kg-1 h-1 dose (4.7 ± 0.7 to 7.3 ± 0.4 mmHg; P = NS). The peak pressure of pyloric phasic pressure waves was 153 ± 28.4 mmHg and their frequency was 4.9 ± 1.1 contractions min-1. Conclusions: CCK-octapeptide elicits both tonic and phasic activity of the pyloric sphincter. The contractile response to a dose of 0.06 μg kg-1 h-1 is greater than the response to 0.02 μg kg-1 h-1.

AB - Background: The purpose of this study was to determine whether a high-resolution solid-state catheter system could detect regional pressure changes within the antrum and pylorus in response to CCK-octapeptide. Methods: Subjects received a 30 min infusion of CCK-octapeptide at either 0.02 or 0.06 μg kg-1 h-1. Results: Five males and two females were studied. Mean antral pressure during phase I MMC increased from 5.3 ± 2.1 to 9.9 ± 2.4 mmHg (P = 0.028) after infusion. At the pylorus, only the 0.06 μg kg-1 h-1 dose increased tonic pressure (8.8 ± 1.4 to 17.6 ± 2.0 mmHg; P = 0.01) as compared with the 0.02 μg kg-1 h-1 dose (4.7 ± 0.7 to 7.3 ± 0.4 mmHg; P = NS). The peak pressure of pyloric phasic pressure waves was 153 ± 28.4 mmHg and their frequency was 4.9 ± 1.1 contractions min-1. Conclusions: CCK-octapeptide elicits both tonic and phasic activity of the pyloric sphincter. The contractile response to a dose of 0.06 μg kg-1 h-1 is greater than the response to 0.02 μg kg-1 h-1.

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ER -

Tonic and phasic pyloric activity in response to CCK-octapeptide

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