Tracking effector and memory NK cells during MCMV infection

Aimee M. Beaulieu, Joseph C. Sun

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

In C57BL/6 mice, NK cells expressing the activating receptor Ly49H proliferate robustly in response to mouse cytomegalovirus (MCMV) infection. The expansion of Ly49H+ NK cells peaks at approximately 1 week post- infection, and is then followed by a distinct contraction phase that ultimately leaves a small but long-lived pool of MCMV-experienced Ly49H+ NK cells that are capable of mediating enhanced memorylike responses during subsequent encounters with MCMV. Here we describe an adoptive transfer model in which the expansion, contraction, and memory cell persistence of transferred Ly49H+ NK cells are tracked in congenic C57BL/6 hosts following MCMV infection.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages1-12
Number of pages12
DOIs
StatePublished - 2016

Publication series

NameMethods in Molecular Biology
Volume1441

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Keywords

  • Innate lymphocytes
  • MCMV
  • Memory
  • NK cells

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