Transforming growth factor beta (TGFβ1, TGFβ2 and TGFβ3) null-mutant phenotypes in embryonic gonadal development

Mushtaq A. Memon, Matthew D. Anway, Trevor R. Covert, Mehmet Uzumcu, Michael K. Skinner

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

The role transforming growth factor beta (TGFb) isoforms TGFb1, TGFb2 and TGFb3 have in the regulation of embryonic gonadal development was investigated with the use of null-mutant (i.e. knockout) mice for each of the TGFb isoforms. Late embryonic gonadal development was investigated because homozygote TGFb null-mutant mice generally die around birth, with some embryonic loss as well. In the testis, the TGFb1 null-mutant mice had a decrease in the number of germ cells at birth, postnatal day 0 (P0). In the testis, the TGFb2 null-mutant mice had a decrease in the number of seminiferous cords at embryonic day 15 (E15). In the ovary, the TGFb2 null-mutant mice had an increase in the number of germ cells at P0. TGFb isoforms appear to have a role in gonadal development, but interactions between the isoforms is speculated to compensate in the different TGFb isoform null-mutant mice.

Original languageEnglish (US)
Pages (from-to)70-80
Number of pages11
JournalMolecular and Cellular Endocrinology
Volume294
Issue number1-2
DOIs
StatePublished - Nov 6 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Molecular Biology
  • Biochemistry

Keywords

  • Embryonic development
  • Knockout
  • Ovary
  • TGF-beta 1
  • TGF-beta 2
  • TGF-beta 3
  • Testis

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