Abstract
This article reviews some recent achievements reported in the area of Translational Bioinformatics (TBI), which has evolved rapidly as result of the Human Genome Project and subsequent -omic projects. Our goal is to support the understanding and enhancement of informatics research and applications at the intersection between medicine and the -omics fields. We discuss current progress and directions in the road ahead for this field, which already involves a significant number of dedicated professionals in research projects and conferences. Through a literature review, a list of topics of informatics research in TBI has been created, including decision support systems, natural language processing, standards, information retrieval, data, text and opinion mining, electronic health records (EHRs), and data integration. We also describe examples of the most challenging categories for research, such as discovery in EHRs, pharmacogenomics, drug repurposing, and genomic testing for individuals. We conclude with an overview of some of the challenges and opportunities presented by this field for research and education, particularly from the perspective of precision medicine.
| Original language | American English |
|---|---|
| Title of host publication | Encyclopedia of Biomedical Engineering |
| Publisher | Elsevier |
| Pages | 507-514 |
| Number of pages | 8 |
| Volume | 1-3 |
| ISBN (Electronic) | 9780128051443 |
| ISBN (Print) | 9780128048290 |
| DOIs | |
| State | Published - Jan 1 2018 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
Keywords
- Bioinformatics
- Drugs discovery
- Medical informatics
- Omics
- Personalized medicine
- Pharmacogenomics
- Precision medicine
- Translational bioinformatics